PMID- 19943495
OWN - NLM
STAT- MEDLINE
DCOM- 20091218
LR  - 20091130
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 34
IP  - 17
DP  - 2009 Sep
TI  - [Effect of constituents combination on pharmacokinetics of Shuxiong tablet].
PG  - 2241-6
AB  - OBJECTIVE: To study the effect of combination components on pharmacokinetics of 
      Shuxiong tablet to provide evidence for the new recipe. METHOD: Six groups of 
      rats (6 for each group) were orally administered with co-extractum of chuanxiong 
      and honghua (CHE), mixed solution of hydroxysafflor yellow A (HSYA) and ferulic 
      acid (FA) (HFM). Panax notoginseng saponins solution (PNS), mixed solution of PNS 
      and CHE (PCHE), mixed solution of PNS and HFM (PHFM) and mixed emulsion of 
      Chuanxiong volatile oil (CVO) and PHFM (CVO-PHFM), respectively. The 
      concentrations of HSYA, FA, ginsnenoside Rg1 and Rb1 in rat plasma were 
      determined by HPLC. Pharmacokinetic parameters (Ka, Kel, Cmax, Tmax and AUC) were 
      calculated by model simulation. The differences of HSYA, FA, Rg1 and Rb1 in 
      pharmacokinetics parameters after administration of six preparations were 
      demonstrated by statistical analysis. RESULT: After oral administration of six 
      preparations to rats, the concentration-time curve of HSYA and Rg1 fitted to 
      one-compartment model, and that of FA fitted to double-compartment model. After 
      oral administration of CHE, Kel of FA reduced; Cmax decreased; but K12 increased, 
      significantly, compared with oral administration of HFM. Other parameters were 
      not significant differences. After co-administration of PNS and CHE (PCHE) or PNS 
      and HFM (PHFM), Ka of HSYA increased; Tmax reduced, significantly. After oral 
      administration of PNS and HFM (PHFM), Ka of Rg1 improved, Tmax decreased, 
      significantly. However, the parameters of FA and Rb1 were not significantly 
      changed. After co-administration of CVO and PHFM (CVO-PHFM), Cmax of Rb1 
      decreased, K12 improved, significantly. Meanwhile, the oral bioavailability of 
      HSYA, FA and Rg1 was improved by 6.056, 2.854 and 2.055 folds, respectively. 
      CONCLUSION: After oral administration of different combinations of Shuxiong 
      tablet constituents, some pharmacokinetics parameters of active ingredients are 
      significantly changed, but the bioavailability is improved only when CVO is 
      co-administered.
FAU - Qi, Jianping
AU  - Qi J
AD  - Department of Phannrmaceutical Sciences, China Pharmaceutical University, Nanjing 
      210009, China. qijp.pharm@gmail.com
FAU - Ping, Qineng
AU  - Ping Q
FAU - Li, Jiangran
AU  - Li J
FAU - Zhuang, Jie
AU  - Zhuang J
FAU - Song, Yunmei
AU  - Song Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Tablets)
SB  - IM
MH  - Animals
MH  - Biological Availability
MH  - Drugs, Chinese Herbal/administration & dosage/*pharmacokinetics
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tablets/administration & dosage/pharmacokinetics
EDAT- 2009/12/01 06:00
MHDA- 2009/12/19 06:00
CRDT- 2009/12/01 06:00
PHST- 2009/12/01 06:00 [entrez]
PHST- 2009/12/01 06:00 [pubmed]
PHST- 2009/12/19 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2009 Sep;34(17):2241-6.