PMID- 19944359
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20221207
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 15
IP  - 10
DP  - 2009 Dec
TI  - Relationship of quality of life scores with baseline characteristics and outcomes 
      in the African-American heart failure trial.
PG  - 835-42
LID - 10.1016/j.cardfail.2009.05.016 [doi]
AB  - BACKGROUND: To characterize the quality of life (QOL) in the African-American 
      Heart Failure Trial (A-HeFT) for factors associated with baseline score, relation 
      of score to prognosis, and response to therapy with a fixed-dose combination of 
      isosorbide dinitrate/hydralazine (FDC I/H). Limited data exist on QOL scores in 
      African-American heart failure patients or on the prognostic value of theses 
      scores in any population. Finally, the effect of FDC I/H on QOL scores, 
      particularly in A-HeFT, is not known. METHODS AND RESULTS: A-HeFT randomized 1050 
      African-American patients with New York Heart Association (NYHA) Class III-IV 
      heart failure and systolic dysfunction. QOL measurements using Minnesota Living 
      with Heart Failure Questionnaire (MLHFQ) were done at baseline and 3-month 
      intervals. At baseline, worse MLHFQ scores were associated with younger age, 
      female sex, greater body mass index, nonischemic etiology, high heart rate and 
      NYHA Class, low systolic blood pressure, and chronic obstructive pulmonary 
      disease. Both baseline and change in MLHFQ score were associated with a higher 
      risk for combined all-cause mortality or heart failure hospitalization (baseline 
      P < .0001, change at 3 months P=.001, and at 6 months P=.0008), but not 
      mortality. Treatment with FDC I/H significantly improved MLHFQ score compared 
      with placebo. CONCLUSIONS: In A-HeFT, baseline QOL (MLHFQ) scores and change in 
      score were predictive of combined HF morbidity and mortality outcomes. FDC I/H 
      consistently improved QOL scores in A-HeFT compared with placebo.
FAU - Carson, Peter
AU  - Carson P
AD  - Veterans Affairs Medical Center, Washington, DC 20422-0001, USA. 
      Peter.Carson@med.va.gov
FAU - Tam, S William
AU  - Tam SW
FAU - Ghali, Jalal K
AU  - Ghali JK
FAU - Archambault, W Tad
AU  - Archambault WT
FAU - Taylor, Anne
AU  - Taylor A
FAU - Cohn, Jay N
AU  - Cohn JN
FAU - Braman, Virginia M
AU  - Braman VM
FAU - Worcel, Manuel
AU  - Worcel M
FAU - Anand, Inder S
AU  - Anand IS
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Adult
MH  - Black or African American/*ethnology/*psychology
MH  - Aged
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*ethnology/*psychology/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life/*psychology
MH  - Research Design/trends
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/12/01 06:00
MHDA- 2010/08/03 06:00
CRDT- 2009/12/01 06:00
PHST- 2009/01/06 00:00 [received]
PHST- 2009/05/28 00:00 [revised]
PHST- 2009/05/29 00:00 [accepted]
PHST- 2009/12/01 06:00 [entrez]
PHST- 2009/12/01 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - S1071-9164(09)00192-4 [pii]
AID - 10.1016/j.cardfail.2009.05.016 [doi]
PST - ppublish
SO  - J Card Fail. 2009 Dec;15(10):835-42. doi: 10.1016/j.cardfail.2009.05.016.