PMID- 19945022
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20220419
IS  - 1878-1594 (Electronic)
IS  - 1521-690X (Linking)
VI  - 23
IP  - 5
DP  - 2009 Oct
TI  - The epidemiology and genetics of pituitary adenomas.
PG  - 543-54
LID - 10.1016/j.beem.2009.05.008 [doi]
AB  - According to data derived from autopsy and radiological imaging series, pituitary 
      tumours occur very commonly in the general population; however, most of these 
      tumours are incidental findings with no obvious clinical impact. The historical 
      data on the prevalence of pituitary adenomas in the clinical setting are scant 
      and point to such tumours being relatively rare. Recent studies have shown that 
      the prevalence of clinically relevant pituitary adenomas is 3-5 times higher than 
      previously reported, which adds impetus to research into the aetiology of these 
      tumours. Although the majority of pituitary adenomas are sporadic, approximately 
      5% of all cases occur in a familial setting and over half of these are due to 
      Multiple Endocrine Neoplasia Type 1 (MEN-1) and Carney's Complex (CNC) disorders. 
      Since the late 1990 s, we have described non-MEN1/CNC familial pituitary tumours 
      that include all tumour phenotypes as a condition termed Familial Isolated 
      Pituitary Adenomas (FIPAs). The clinical characteristics of the FIPAs vary from 
      those sporadic pituitary adenomas, as patients with FIPAs have a younger age at 
      diagnosis and larger tumours. About 15% of the FIPA patients have mutations in 
      the aryl hydrocarbon receptor-interacting protein gene (AIP), which indicates 
      that the FIPA may have a diverse genetic pathophysiology.
FAU - Daly, Adrian F
AU  - Daly AF
AD  - Department of Endocrinology, Centre Hospitalier Universitaire de Liege, 
      University of Liege, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium.
FAU - Tichomirowa, Maria A
AU  - Tichomirowa MA
FAU - Beckers, Albert
AU  - Beckers A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Endocrinol Metab
JT  - Best practice & research. Clinical endocrinology & metabolism
JID - 101120682
SB  - IM
MH  - Adenoma/*epidemiology/*genetics/pathology
MH  - Autopsy
MH  - Carney Complex/epidemiology/genetics
MH  - Humans
MH  - Multiple Endocrine Neoplasia/complications/epidemiology/genetics
MH  - Pituitary Neoplasms/*epidemiology/*genetics/pathology
MH  - Population
MH  - Registries
RF  - 101
EDAT- 2009/12/01 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/12/01 06:00
PHST- 2009/12/01 06:00 [entrez]
PHST- 2009/12/01 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - S1521-690X(09)00056-6 [pii]
AID - 10.1016/j.beem.2009.05.008 [doi]
PST - ppublish
SO  - Best Pract Res Clin Endocrinol Metab. 2009 Oct;23(5):543-54. doi: 
      10.1016/j.beem.2009.05.008.