PMID- 19945172
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20210301
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 124
IP  - 1-2
DP  - 2010 Jul
TI  - Self-referential processing and the prefrontal cortex over the course of 
      depression: a pilot study.
PG  - 196-201
LID - 10.1016/j.jad.2009.11.003 [doi]
AB  - BACKGROUND: Depressed patients exhibit cognitive biases, including maladaptive 
      self-focus. In a previous functional magnetic resonance imaging (fMRI) study, the 
      dorsal medial prefrontal cortex (MPFC) activation during self-referential versus 
      semantic processing was unique to patients, as was the left dorsolateral 
      prefrontal cortex (DLPFC) activation. The aim of this pilot study was to examine 
      whether this pattern was stable over the course of depression. METHODS: Sixteen 
      participants (8 depressed inpatients, 8 healthy controls) viewed personality 
      traits during fMRI and judged whether each trait described them or not ('self' 
      condition), or whether it described a socially desirable trait or not ('general' 
      condition). There were 2 scanning sessions with an interval of at least 6weeks, 
      in which patients received an antidepressant treatment. RESULTS: After a mean 
      duration of 9 weeks, depressed patients displayed a more balanced activation of 
      the left DLPFC but a greater activation of the dorsal MPFC in 'self' versus 
      'general' condition remained. LIMITATIONS: The small sample size and 
      heterogeneous clinical features prevented subgroups analyses between responders 
      and non-responders. CONCLUSIONS: The change of the left DLPFC activation suggests 
      that antidepressants are associated with a more balanced allocation of cognitive 
      control across self-referential and non-self-referential processes. The apparent 
      lack of effect on the dorsal MPFC activity is consistent with the specific 
      effects of antidepressants versus cognitive behavior therapy (CBT) previously 
      demonstrated in depression. Future studies could examine the relationships 
      between the dorsal MPFC activity in depressed patients and the need to reduce 
      self-focus through CBT to achieve remission and prevent relapse.
FAU - Lemogne, Cedric
AU  - Lemogne C
AD  - CNRS USR 3246, Pitie-Salpetriere Hospital, Paris, France. 
      cedric.lemogne@orange.fr
FAU - Mayberg, Helen
AU  - Mayberg H
FAU - Bergouignan, Loretxu
AU  - Bergouignan L
FAU - Volle, Emmanuelle
AU  - Volle E
FAU - Delaveau, Pauline
AU  - Delaveau P
FAU - Lehericy, Stephane
AU  - Lehericy S
FAU - Allilaire, Jean-Francois
AU  - Allilaire JF
FAU - Fossati, Philippe
AU  - Fossati P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091127
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Cognition Disorders/diagnosis/drug therapy/*physiopathology/psychology
MH  - Depressive Disorder/diagnosis/drug therapy/*physiopathology/psychology
MH  - Dominance, Cerebral/physiology
MH  - Female
MH  - Humans
MH  - Judgment/drug effects/physiology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Personality Inventory/statistics & numerical data
MH  - Pilot Projects
MH  - Prefrontal Cortex/drug effects/*physiopathology
MH  - Psychometrics
MH  - *Self Concept
MH  - Social Desirability
MH  - Young Adult
EDAT- 2009/12/01 06:00
MHDA- 2010/08/24 06:00
CRDT- 2009/12/01 06:00
PHST- 2009/08/06 00:00 [received]
PHST- 2009/11/09 00:00 [revised]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2009/12/01 06:00 [entrez]
PHST- 2009/12/01 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - S0165-0327(09)00496-0 [pii]
AID - 10.1016/j.jad.2009.11.003 [doi]
PST - ppublish
SO  - J Affect Disord. 2010 Jul;124(1-2):196-201. doi: 10.1016/j.jad.2009.11.003. Epub 
      2009 Nov 27.