PMID- 19945836
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20220310
IS  - 1879-0410 (Electronic)
IS  - 0955-0674 (Print)
IS  - 0955-0674 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Apr
TI  - mTOR and cancer: many loops in one pathway.
PG  - 169-76
LID - 10.1016/j.ceb.2009.10.007 [doi]
AB  - The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and 
      division that responds to a variety of stimuli, including nutrient, energy, and 
      growth factors. In the last years, a significant number of pieces have been added 
      to the puzzle of how mTOR coordinates and executes its functions. Extensive 
      research on mTOR has also uncovered a complex network of regulatory loops that 
      impact the therapeutic approaches aimed at targeting mTOR.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Efeyan, Alejo
AU  - Efeyan A
AD  - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 
      02142, United States.
FAU - Sabatini, David M
AU  - Sabatini DM
LA  - eng
GR  - R01 CA129105-02/CA/NCI NIH HHS/United States
GR  - R01 GM072555/GM/NIGMS NIH HHS/United States
GR  - R01 CA129105/CA/NCI NIH HHS/United States
GR  - R01 GM072555-04/GM/NIGMS NIH HHS/United States
GR  - R01 AI047389/AI/NIAID NIH HHS/United States
GR  - R01 CA103866/CA/NCI NIH HHS/United States
GR  - R01 AI047389-10/AI/NIAID NIH HHS/United States
GR  - R01 CA103866-05/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091127
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Feedback, Physiological/drug effects
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/antagonists & 
      inhibitors/*metabolism
MH  - Neoplasms/*enzymology
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Protein Serine-Threonine Kinases/antagonists & inhibitors/*metabolism
MH  - *Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases
PMC - PMC2854285
MID - NIHMS161958
EDAT- 2009/12/01 06:00
MHDA- 2010/06/24 06:00
PMCR- 2011/04/01
CRDT- 2009/12/01 06:00
PHST- 2009/10/20 00:00 [received]
PHST- 2009/10/23 00:00 [accepted]
PHST- 2009/12/01 06:00 [entrez]
PHST- 2009/12/01 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - S0955-0674(09)00190-2 [pii]
AID - 10.1016/j.ceb.2009.10.007 [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/j.ceb.2009.10.007. Epub 
      2009 Nov 27.