PMID- 19947489
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20181201
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 26
IP  - 5
DP  - 2009 Oct
TI  - [Mineralization of PLGA-[ASP-PEG] modified with RGD-containing peptide].
PG  - 1056-9
AB  - The RGD-containing peptide was used to modify the surface of porous 
      PLGA-[ASP-PEG], and was incubated in the modified simulated body fluid (mSBF) for 
      two weeks. The mineralization of PLGA-[ASP-PEG] was explored. The active peptide 
      was used to modify PLGA-[ASP-PEG] through cross-linker (Sulfo-LC-SPDP), 
      characterized by X-ray photoelectron spectroscopy (XPS) the peptide-modified 
      PLGA-[ASP-PEG] (Experiment group, EG) and PLGA-[ASP-PEG] without modification 
      (Control group, CG) were all incubated in mSBF for two weeks, confirmed by 
      observation of Scanning electron microscope(SEM) and measurements of Energy 
      dispersive analysis system of X-ray (EDS) and X-ray diffractometry (XRD). XPS 
      indicated that the binding energy of sulphur in EG was 164eV, and the ratio of 
      carbon to sulphur in EG was 99.746 : 0.1014, however, sulphur was not detected in 
      CG; SEM analysis demonstrated that the mineralization layers were more 
      consecutive and compact in EG than in CG. The results of EDS and XRD indicated 
      that the main component of mineral was hydroxyapatite, and the ratio of Ca/P was 
      1.60 in EG, and 1.52 in CG. RGD-containing peptide provided enough functional 
      groups for mineralization; the mineralized peptide- modified PLGA-[ASP-PEG] 
      possessed the bonelike microstructure.
FAU - Song, Yulin
AU  - Song Y
AD  - Department of Orthopaedics, Second Affiliated Hospital, Nanchang University, 
      Nanchang 330006, China.
FAU - Zheng, Qixin
AU  - Zheng Q
FAU - Zheng, Jianfeng
AU  - Zheng J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 0 (Oligopeptides)
RN  - 0 (Peptides)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 78VO7F77PN (arginyl-glycyl-aspartic acid)
SB  - IM
MH  - Biocompatible Materials/chemistry
MH  - *Bone Substitutes
MH  - Bone and Bones/metabolism
MH  - *Calcification, Physiologic
MH  - Lactic Acid/*chemistry
MH  - Oligopeptides/*chemistry
MH  - Osteogenesis/drug effects
MH  - Peptides/chemical synthesis/*pharmacology
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Surface Properties
EDAT- 2009/12/02 06:00
MHDA- 2011/12/16 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Oct;26(5):1056-9.