PMID- 19948880
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20181201
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Apr
TI  - Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats.
PG  - 1051-9
LID - 10.1093/ndt/gfp604 [doi]
AB  - BACKGROUND: Pleiotropic effects of statins represent potential mechanisms for the 
      treatment of end organ damage in hypertension. This study has investigated the 
      effects of rosuvastatin (10 mg/kg/day) on renal function impairment, 
      glomerulosclerosis and tubulointerstitial fibrosis in deoxycorticosterone acetate 
      (DOCA)-salt hypertensive (DSH) rat. METHODS: Rats were implanted with DOCA strips 
      (200 mg/kg) on 1 week after unilateral nephrectomy. Rats received a controlled 
      diet with or without rosuvastatin. Three weeks after DOCA implantation, systolic 
      blood pressure (SBP) was measured by tail-cuff method. The glomerulosclerosis and 
      tubulointerstitial fibrosis was determined by Masson's trichrome stain. The 
      tumour necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta), 
      interferon-gamma (IFN-gamma), monocyte chemoattractant protein1 (MCP1), 
      intercellular adhesion molecule-1 (ICAM-1) and endothelin-1 (ET-1) were 
      determined by real-time polymerase chain reaction. The expression of ED-1, 
      transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor 
      (CTGF) was determined in the kidney by immunoblotting and immunohistochemistry. 
      RESULTS: In DSH rats, SBP was increased, which was not affected by rosuvastatin 
      treatment. Creatinine clearance was decreased while urinary albumin excretion 
      ratio was increased in DSH rats compared with controls, which were attenuated by 
      rosuvastatin treatment. Glomerulosclerosis and tubulointerstitial fibrosis in DSH 
      rats were attenuated by rosuvastatin treatment. The messenger RNA expression of 
      TNF-alpha, IL-1beta, IFN-gamma, MCP1, ICAM-1 and ET-1 was increased in DSH, which 
      was attenuated by rosuvastatin treatment. The expression of ED-1, TGF-beta and 
      CTGF was increased in the kidney of DSH, which was counteracted by rosuvastatin 
      treatment. CONCLUSION: Rosuvastatin is effective in preventing progression of 
      renal injury in DSH, the mechanism of which is associated with anti-inflammatory 
      and anti-fibrotic effects.
FAU - Bae, Eun Hui
AU  - Bae EH
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju 501-757, Korea.
FAU - Kim, In Jin
AU  - Kim IJ
FAU - Park, Jeong Woo
AU  - Park JW
FAU - Ma, Seong Kwon
AU  - Ma SK
FAU - Lee, Jong Un
AU  - Lee JU
FAU - Kim, Soo Wan
AU  - Kim SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091130
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Biomarkers)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Mineralocorticoids)
RN  - 0 (PPAR gamma)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 0 (Thiazolidinediones)
RN  - 05V02F2KDG (Rosiglitazone)
RN  - 40GP35YQ49 (Desoxycorticosterone)
SB  - IM
MH  - Animals
MH  - Biomarkers/analysis
MH  - Blood Pressure/drug effects
MH  - Blotting, Western
MH  - Desoxycorticosterone/*adverse effects
MH  - Glomerulonephritis/etiology/pathology/*prevention & control
MH  - Hypertension/*chemically induced/complications/metabolism
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Immunoenzyme Techniques
MH  - Inflammation/genetics/metabolism
MH  - Male
MH  - Mineralocorticoids/adverse effects
MH  - Nephritis, Interstitial/etiology/pathology/*prevention & control
MH  - PPAR gamma/agonists
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Rosiglitazone
MH  - Sodium Chloride, Dietary/administration & dosage
MH  - Thiazolidinediones/*therapeutic use
EDAT- 2009/12/02 06:00
MHDA- 2010/08/18 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - gfp604 [pii]
AID - 10.1093/ndt/gfp604 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2010 Apr;25(4):1051-9. doi: 10.1093/ndt/gfp604. Epub 
      2009 Nov 30.