PMID- 19949081
OWN - NLM
STAT- MEDLINE
DCOM- 20100108
LR  - 20171116
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 184
IP  - 1
DP  - 2010 Jan 1
TI  - Cutting edge: limited specialization of dendritic cell subsets for MHC class 
      II-associated presentation of viral particles.
PG  - 26-9
LID - 10.4049/jimmunol.0901540 [doi]
AB  - Dendritic cells (DCs) are the most important APC. It was recently reported that 
      there is a dichotomy for Ag presentation by DC subsets; exogenous Ags reach the 
      MHC class I pathway, but not the MHC class II pathway, in CD8(+) DCs, whereas 
      CD8(-) DCs only process Ags for the MHC class II pathway. In this study, we used 
      virus-like particles (VLPs) to show that CD8(+) and CD8(-) DCs efficiently 
      capture and process VLPs for presentation in association with MHC class II in 
      vivo. In contrast, CD8(+) DCs, but not CD8(-) DCs, cross presented VLP-derived 
      peptides. This pattern was changed in an FcgammaR-dependent fashion in the 
      presence of VLP-specific Abs, because under those conditions both DC subsets 
      failed to efficiently cross present. Thus, the presentation of viral particles to 
      CD4(+) T cells is not restricted to distinct DC subsets, whereas the presentation 
      of viral particles to CD8(+) T cells is limited to CD8(+) DCs.
FAU - Keller, Susanne A
AU  - Keller SA
AD  - Cytos Biotechnology AG, Zurich-Schlieren, Switzerland.
FAU - Bauer, Monika
AU  - Bauer M
FAU - Manolova, Vania
AU  - Manolova V
FAU - Muntwiler, Simone
AU  - Muntwiler S
FAU - Saudan, Philippe
AU  - Saudan P
FAU - Bachmann, Martin F
AU  - Bachmann MF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091130
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, Viral)
RN  - 0 (CD8 Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Antigens, Viral/immunology
MH  - CD8 Antigens/immunology
MH  - Cross-Priming/immunology
MH  - Dendritic Cells/*immunology
MH  - Flow Cytometry
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Virion/*immunology
EDAT- 2009/12/02 06:00
MHDA- 2010/01/09 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2010/01/09 06:00 [medline]
AID - jimmunol.0901540 [pii]
AID - 10.4049/jimmunol.0901540 [doi]
PST - ppublish
SO  - J Immunol. 2010 Jan 1;184(1):26-9. doi: 10.4049/jimmunol.0901540. Epub 2009 Nov 
      30.