PMID- 19949664 OWN - NLM STAT- MEDLINE DCOM- 20100127 LR - 20211020 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 24 IP - 6 DP - 2009 Dec TI - Gender difference in the prodromal symptoms of first-episode schizophrenia. PG - 1083-8 LID - 10.3346/jkms.2009.24.6.1083 [doi] AB - To investigate the gender difference of early symptoms appearing before the onset of the psychotic symptoms in patients with first-episode schizophrenia, we reviewed the medical records of 63 patients (38 males, 25 females), who were hospitalized for first-episode schizophrenia. The frequency and duration of prodromal and psychotic symptoms, Clinical Global Impression scale scores, Global Assessment of Functioning (GAF) scale scores at admission, and other clinical characteristics were recorded for all patients. Overall, the most common prodromal symptoms were attenuated positive symptoms (89%), followed by mood symptoms (86%). Negative symptoms were the most common in male patients (97.4%), whereas attenuated positive symptoms were the most common in female patients (84%). Male patients demonstrated more frequent negative, cognitive, and obsessive-compulsive symptoms than female patients did and also showed a tendency of having negative symptoms for the longer period. Correlational analysis showed a significant negative correlation between the duration of negative symptoms and GAF scores at admission in male patients. Our findings suggest that different patterns of prodromal symptoms between male and female begin before the onset of the psychosis. Further prospective studies should be needed. FAU - Choi, Jung-Seok AU - Choi JS AD - Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Korea. FAU - Chon, Myong-Wuk AU - Chon MW FAU - Kang, Do-Hyung AU - Kang DH FAU - Jung, Myung Hun AU - Jung MH FAU - Kwon, Jun Soo AU - Kwon JS LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20091109 PL - Korea (South) TA - J Korean Med Sci JT - Journal of Korean medical science JID - 8703518 SB - IM MH - Adolescent MH - Adult MH - Age of Onset MH - Female MH - Humans MH - Male MH - Neuropsychological Tests MH - Psychiatric Status Rating Scales MH - Schizophrenia/diagnosis/*physiopathology MH - Sex Factors MH - Young Adult PMC - PMC2775856 OTO - NOTNLM OT - First-episode Schizophrenia OT - Prodrome of Schizophrenia OT - Schizophrenia OT - Sex Factors EDAT- 2009/12/02 06:00 MHDA- 2010/01/28 06:00 PMCR- 2009/12/01 CRDT- 2009/12/02 06:00 PHST- 2008/08/31 00:00 [received] PHST- 2008/12/12 00:00 [accepted] PHST- 2009/12/02 06:00 [entrez] PHST- 2009/12/02 06:00 [pubmed] PHST- 2010/01/28 06:00 [medline] PHST- 2009/12/01 00:00 [pmc-release] AID - 10.3346/jkms.2009.24.6.1083 [doi] PST - ppublish SO - J Korean Med Sci. 2009 Dec;24(6):1083-8. doi: 10.3346/jkms.2009.24.6.1083. Epub 2009 Nov 9.