PMID- 19949672
OWN - NLM
STAT- MEDLINE
DCOM- 20100127
LR  - 20211020
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 24
IP  - 6
DP  - 2009 Dec
TI  - The utility of fluorescence in situ hybridization for detection of bladder 
      urothelial carcinoma in routine clinical practice.
PG  - 1139-44
LID - 10.3346/jkms.2009.24.6.1139 [doi]
AB  - To evaluate the ability of fluorescence in situ hybridization (FISH) in detecting 
      bladder urothelial carcinoma (BUC), FISH and cytology were compared for the 
      evaluation of 308 consecutive urine samples from patients suspected of having 
      BUC. All patients underwent cystoscopy for identification of bladder lesions. The 
      FISH results were compared with the cytology assessment. In all, 122 patients had 
      confirmed BUC. Among them, 68 (55.7%) were FISH-positive, while only 33 (27%) 
      were positive on cytology. According to disease stage (superficial vs. invasive) 
      and grade (low vs. high), the sensitivities of FISH were also significantly 
      higher than those of cytology in all categories. Moreover, in 36 patients who had 
      no visible tumor with flat, erythematous mucosa (suspicious lesion), FISH was 
      more sensitive than cytology for the detection of BUC (83.3% vs. 33.3%, P=0.002). 
      The FISH was negative in 168 (90.3%) of 186 patients with no histological 
      evidence of BUC or negative cystoscopy findings. The sensitivity of FISH for 
      detecting BUC was superior to that of cytology, regardless of tumor stage and 
      grade. FISH is a significant additional and complementary method for detection of 
      BUC in patients who have suspicious lesions on cystoscopy.
FAU - Kwak, Kyung Won
AU  - Kwak KW
AD  - Department of Urology, KEPCO (Korea Electric Power Corporation) Medical 
      Foundation, Hanil General Hospital, Seoul, Korea.
FAU - Kim, Sun Hee
AU  - Kim SH
FAU - Lee, Hyun Moo
AU  - Lee HM
LA  - eng
PT  - Journal Article
DEP - 20091109
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Aged
MH  - Carcinoma, Transitional Cell/diagnosis/*pathology
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence/methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Urinary Bladder Neoplasms/*diagnosis/pathology
MH  - Urine/cytology
MH  - Urothelium/*pathology
PMC - PMC2775864
OTO - NOTNLM
OT  - Bladder Urothelial Carcinoma
OT  - Cytology
OT  - In Situ Hybridization, Fluorescence
EDAT- 2009/12/02 06:00
MHDA- 2010/01/28 06:00
PMCR- 2009/12/01
CRDT- 2009/12/02 06:00
PHST- 2008/12/04 00:00 [received]
PHST- 2009/01/20 00:00 [accepted]
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2010/01/28 06:00 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - 10.3346/jkms.2009.24.6.1139 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2009 Dec;24(6):1139-44. doi: 10.3346/jkms.2009.24.6.1139. Epub 
      2009 Nov 9.