PMID- 19949866
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20220409
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 55
IP  - 2
DP  - 2010 Feb
TI  - Effect of meal ingestion on ileocolonic and colonic transit in health and 
      irritable bowel syndrome.
PG  - 384-91
LID - 10.1007/s10620-009-1041-8 [doi]
AB  - BACKGROUND: Postprandial symptoms in irritable bowel syndrome (IBS) have been 
      associated with increased bowel contractility. AIM: To compare ileocolonic and 
      colonic responses to feeding in health and IBS. METHODS: We prospectively 
      analyzed data from separate research trials in 122 IBS patients and 41 healthy 
      volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling 
      [CF]3h) and immediately after (CF4 h) a standard lunch at 3 h 45 min, and 2 h 
      thereafter. The colonic geometric center (GC) was calculated 2 h (GC6 h) after 
      lunch ingested at 4 h (GC4 h) and directly after (GC8 h) a standard dinner 
      ingested at 7 h 45 min. RESULTS: ICT immediately after eating was higher in IBS 
      diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 +/- 2.4 
      vs. 17.5 +/- 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P 
      = 0.55). There was significant overall group differences in colonic transit 2 h 
      post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; 
      GC6-GC4, delta 0.29 +/- 0.08) patients versus healthy volunteers (delta 0.56 +/- 
      0.12 GC units). CONCLUSIONS: After feeding, ICT is increased in IBS-D, whereas 
      colonic transit is blunted in IBS-C.
FAU - Deiteren, Annemie
AU  - Deiteren A
AD  - Clinical Enteric Neuroscience Translational and Epidemiological Research, College 
      of Medicine, Mayo Clinic, Charlton 8-110, 200 First St SW, Rochester, MN 55905, 
      USA.
FAU - Camilleri, Michael
AU  - Camilleri M
FAU - Burton, Duane
AU  - Burton D
FAU - McKinzie, Sanna
AU  - McKinzie S
FAU - Rao, Archana
AU  - Rao A
FAU - Zinsmeister, Alan R
AU  - Zinsmeister AR
LA  - eng
GR  - R01 DK054681/DK/NIDDK NIH HHS/United States
GR  - R01 DK054681-08/DK/NIDDK NIH HHS/United States
GR  - R01 DK-54681/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 7440-26-8 (Technetium)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Colon/*physiology
MH  - Eating/*physiology
MH  - Female
MH  - Food
MH  - Gastrointestinal Transit/*physiology
MH  - Humans
MH  - Ileum/*physiology
MH  - Irritable Bowel Syndrome/diagnostic imaging/*physiopathology
MH  - Male
MH  - Radionuclide Imaging
MH  - Reference Values
MH  - Technetium/administration & dosage
PMC - PMC2900583
MID - NIHMS215947
EDAT- 2009/12/02 06:00
MHDA- 2010/02/19 06:00
PMCR- 2011/02/01
CRDT- 2009/12/02 06:00
PHST- 2009/08/04 00:00 [received]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - 10.1007/s10620-009-1041-8 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2010 Feb;55(2):384-91. doi: 10.1007/s10620-009-1041-8.