PMID- 19950775
OWN - NLM
STAT- MEDLINE
DCOM- 20091215
LR  - 20191210
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 56
IP  - 94-95
DP  - 2009 Sep-Oct
TI  - Comparison of an ecabet sodium and proton pump inhibitor (PPI) combination 
      therapy with PPI alone in the treatment of endoscopic submucosal dissection 
      (ESD)--induced ulcers in early gastric cancer: prospective randomized study.
PG  - 1270-3
AB  - BACKGROUND/AIMS: Ecabet sodium (ES) is a widely employed mucoprotective agent, 
      for the treatment of gastric ulcers. The present paper prospectively evaluate the 
      additive benefits of using ES in combination with the rabeprazole proton pump 
      inhibitor (PPI) for the treatment of gastric ulcers after endoscopic submucosal 
      dissection (ESD). METHODOLOGY: A total of 56 patients who had undergone ESD for 
      early gastric cancers were randomly assigned to receive either PPI with ES (P/ES 
      group, n=28) or PPI alone (PPI group, n=28) for 8 weeks. At 4 and 8 weeks after 
      ESD, the healing rate and the diminution rate of the ulcers were compared between 
      two groups by endoscopy. RESULTS: One patient in the PPI group developed a 
      hemorrhage as a result of an ESD-induced ulcer. At 4 weeks, the healing rates 
      were significantly higher in the P/ES group (40.7%) compared with the PPI group 
      (11.5%), (p = 0.0013). This tendency was observed also at 8 weeks (p = 0.0446). 
      In addition, at 4 weeks, the diminution rates of the ESD-induced ulcers were 
      significantly higher in the P/ES group (95.8%) than in the PPI group (84.9%), 
      (p=0.0033). CONCLUSIONS: ES in combination with PPI facilitates increased healing 
      of ESD-induced ulcers, and can also improve the quality of ulcer healing.
FAU - Asakuma, Yutaka
AU  - Asakuma Y
AD  - Department of Gastroenterology and Hepatology, Kinki University, School of 
      Medicine, 377-2 Ohno-Higashi, Osaka-sayama 589-8511, Japan.
FAU - Kudo, Masatoshi
AU  - Kudo M
FAU - Matsui, Shigenaga
AU  - Matsui S
FAU - Okada, Mumon
AU  - Okada M
FAU - Kawasaki, Masanori
AU  - Kawasaki M
FAU - Umehara, Yasushi
AU  - Umehara Y
FAU - Ichikawa, Tsutomu
AU  - Ichikawa T
FAU - Kitai, Satoshi
AU  - Kitai S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Abietanes)
RN  - 0 (Proton Pump Inhibitors)
RN  - 2K02669KWP (ecabet)
SB  - IM
MH  - Abietanes/*administration & dosage
MH  - Aged
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gastric Mucosa/*surgery
MH  - Gastroscopy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*drug therapy
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/administration & dosage/*therapeutic use
MH  - Stomach Neoplasms/*surgery
MH  - Stomach Ulcer/*drug therapy/etiology/physiopathology
MH  - Wound Healing
EDAT- 2009/12/03 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1270-3.