PMID- 19952769
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20151119
IS  - 1932-751X (Electronic)
IS  - 1932-7501 (Linking)
VI  - 30
IP  - 2
DP  - 2010 Mar-Apr
TI  - Comparative value of NYHA functional class and quality-of-life questionnaire 
      scores in assessing heart failure.
PG  - 101-5
LID - 10.1097/HCR.0b013e3181be7e47 [doi]
AB  - PURPOSE: To assess the relationships between New York Heart Association (NYHA) 
      functional class, quality of life, aerobic capacity (peak oxygen uptake, (.)VO2), 
      ventilatory efficiency (minute ventilation/carbon dioxide production slope, 
      VE/(.)VCO2 slope), and brain natriuretic peptide (BNP) in creating a model for 
      predicting peak (.)VO2). METHODS: Cardiopulmonary exercise testing was performed 
      in 62 patients. A baseline blood sample was taken to measure the N-terminal 
      prohormone BNP (NT-proBNP). Patients also completed the Minnesota Living with 
      Heart Failure Questionnaire (MLHF) and the Specific Activity Questionnaire (SAQ), 
      and NYHA functional class was determined. RESULTS: NYHA functional class 
      correlated more strongly with SAQ score than with MLHF score. Peak (.)VO2 and 
      VE/(.)VCO2 slope had stronger associations with NYHA functional class and SAQ 
      score than with MLHF score. NT-proBNP plasma levels correlated more significantly 
      with NYHA functional class and SAQ score (both P < .001) than with MLHF score. 
      Using multiple linear regression analysis adjusted for age and sex, SAQ score, 
      NT-proBNP, and etiology of heart failure had significant independent 
      relationships with peak (.)VO2, explaining 63% of its variability (adjusted R(2) 
      = 0.596). CONCLUSIONS: Cardiopulmonary exercise variables and plasma NT-proBNP 
      are associated more with NYHA functional class and SAQ score than with MLHF 
      score. When combined, SAQ score, NT-proBNP, and etiology of heart failure can 
      satisfactorily predict peak oxygen uptake.
FAU - Athanasopoulos, Leonidas V
AU  - Athanasopoulos LV
AD  - 1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Dritsas, Athanasios
AU  - Dritsas A
FAU - Doll, Helen A
AU  - Doll HA
FAU - Cokkinos, Dennis V
AU  - Cokkinos DV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiopulm Rehabil Prev
JT  - Journal of cardiopulmonary rehabilitation and prevention
JID - 101291247
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Cardiomyopathy, Dilated/*diagnosis/rehabilitation/therapy
MH  - Exercise
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Female
MH  - Health Status Indicators
MH  - Heart Failure/*diagnosis/rehabilitation/therapy
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Ischemia/*diagnosis/rehabilitation/therapy
MH  - Natriuretic Peptide, Brain/blood
MH  - Oxygen Consumption
MH  - Peptide Fragments/blood
MH  - Psychometrics
MH  - *Quality of Life
MH  - Surveys and Questionnaires
EDAT- 2009/12/03 06:00
MHDA- 2011/06/03 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1097/HCR.0b013e3181be7e47 [doi]
PST - ppublish
SO  - J Cardiopulm Rehabil Prev. 2010 Mar-Apr;30(2):101-5. doi: 
      10.1097/HCR.0b013e3181be7e47.