PMID- 19952828
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20220317
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 42
IP  - 4
DP  - 2010 Apr
TI  - Exercise without weight loss does not reduce C-reactive protein: the INFLAME 
      study.
PG  - 708-16
LID - 10.1249/MSS.0b013e3181c03a43 [doi]
AB  - PURPOSE: Numerous cross-sectional studies have observed an inverse association 
      between C-reactive protein (CRP) and physical activity. Exercise training trials 
      have produced conflicting results, but none of these studies was specifically 
      designed to examine CRP. The objective of the Inflammation and Exercise (INFLAME) 
      study was to examine whether aerobic exercise training without dietary 
      intervention can reduce CRP in individuals with elevated CRP. METHODS: The study 
      was a randomized controlled trial of 162 sedentary men and women with elevated 
      CRP (> or = 2.0 mg.L(-1)). Participants were randomized into a nonexercise 
      control group or an exercise group that trained for 4 months. The primary outcome 
      was change in CRP. RESULTS: The study participants had a mean (SD) age of 49.7 
      (10.9) yr and a mean body mass index of 31.8 (4.0) kg.m(-2). The median 
      (interquartile range (IQR)) and mean baseline CRP levels were 4.1 (2.5-6.1) and 
      4.8 (3.4) mg.L(-1), respectively. In the exercise group, median exercise 
      compliance was 99.9%. There were no differences in median (IQR) change in CRP 
      between the control and exercise groups (0.0 (-0.5 to 0.9) vs 0.0 (-0.8 to 0.7) 
      mg.L(-1), P = 0.4). The mean (95% confidence interval) change in CRP adjusted for 
      gender and baseline weight was similar in the control and exercise groups, with 
      no significant difference between groups (0.5 (-0.4 to 1.3) vs 0.4 (-0.5 to 1.2) 
      mg.L(-1), P = 0.9). Change in weight was correlated with change in CRP. 
      CONCLUSIONS: Exercise training without weight loss is not associated with a 
      reduction in CRP.
FAU - Church, Timothy S
AU  - Church TS
AD  - Pennington Biomedical Research Center, Louisiana State University System, Baton 
      Rouge, LA 70808-4124, USA. tim.church@pbrc.edu
FAU - Earnest, Conrad P
AU  - Earnest CP
FAU - Thompson, Angela M
AU  - Thompson AM
FAU - Priest, Elisa L
AU  - Priest EL
FAU - Rodarte, Ruben Q
AU  - Rodarte RQ
FAU - Saunders, Travis
AU  - Saunders T
FAU - Ross, Robert
AU  - Ross R
FAU - Blair, Steven N
AU  - Blair SN
LA  - eng
SI  - ClinicalTrials.gov/NCT00113061
GR  - R01 HL066262/HL/NHLBI NIH HHS/United States
GR  - R01 HL075442/HL/NHLBI NIH HHS/United States
GR  - R01 HL075442-05/HL/NHLBI NIH HHS/United States
GR  - HL66262/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - C-Reactive Protein/*analysis
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Inflammation/metabolism
MH  - Male
MH  - Middle Aged
MH  - Sedentary Behavior
MH  - Weight Loss/*physiology
PMC - PMC2919641
MID - NIHMS198748
EDAT- 2009/12/03 06:00
MHDA- 2011/04/08 06:00
PMCR- 2011/04/01
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - 10.1249/MSS.0b013e3181c03a43 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2010 Apr;42(4):708-16. doi: 10.1249/MSS.0b013e3181c03a43.