PMID- 19954849
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20161125
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Feb
TI  - POP levels in breast milk and maternal serum and thyroid hormone levels in 
      mother-child pairs from Uppsala, Sweden.
PG  - 180-7
LID - 10.1016/j.envint.2009.11.001 [doi]
AB  - In experimental studies, it has frequently been observed that the homeostasis of 
      thyroid hormones (THs) is affected by exposure to persistent organic pollutants 
      (POPs), such as dioxins and PCBs. In man, similar effects have been indicated in 
      several epidemiological studies. In order to investigate the possible effect on 
      THs at low background exposures found among the Swedish population the following 
      study was performed. Primiparous women (n=395) in the Uppsala region were 
      recruited between 1996 and 1999. Of these, 325 mothers agreed to donate a serum 
      sample in late pregnancy and breast milk was obtained from 211 women 3 weeks 
      after delivery. Babies were sampled for blood at 3 weeks (n=150) and 3 months 
      (n=115) after birth. In connection to the sampling, questions on personal 
      characteristics were asked. Levels of low (tri- to penta-) chlorinated PCB, 
      di-ortho PCB, p,p'-DDE, (mono-ortho) PCB TEQ and PCDD/DF TEQ were monitored in 
      breast milk and in mother's blood (not PCDD/DF). The results showed that the 
      measured TH levels (thyroid-stimulating hormone - TSH, total tri-iodothyronine - 
      TT3, free thyroxine - FT4) in mothers and children were within the reference 
      range. Some significant associations were seen between POP exposures and TH 
      levels in mother or child after simple regression analysis. Following adjustment 
      for important confounding factors, the significant associations mostly 
      disappeared. However, significantly decreasing TT3 levels with increasing 
      prenatal low-chlorinated PCB exposure were still seen in 3 week old children, and 
      on TT3 in mothers exposed to PCDD/DF. In conclusion, the study clearly shows the 
      importance of adjustment for important confounding factors in the analysis of 
      possible associations between POP exposure and hormonal effects. The remaining 
      associations are weak in both children and mothers and the clinical consequences 
      of these alterations are uncertain. When comparing studies that investigate 
      associations between TH levels and POP levels during the perinatal stage, no 
      obvious between-study concordance was seen regarding the critical dose for 
      hormonal effects to occur.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Darnerud, P O
AU  - Darnerud PO
AD  - National Food Administration, PO Box 622, 751 26 Uppsala, Sweden. poda@slv.se
FAU - Lignell, S
AU  - Lignell S
FAU - Glynn, A
AU  - Glynn A
FAU - Aune, M
AU  - Aune M
FAU - Tornkvist, A
AU  - Tornkvist A
FAU - Stridsberg, Mats
AU  - Stridsberg M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091201
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Thyroid Hormones)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Dichlorodiphenyl Dichloroethylene/blood/metabolism
MH  - Environmental Monitoring
MH  - Environmental Pollutants/blood/*metabolism
MH  - Female
MH  - Homeostasis/drug effects
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - *Maternal Exposure
MH  - Maternal-Fetal Exchange
MH  - Milk, Human/*metabolism
MH  - Organic Chemicals/blood/*metabolism
MH  - Polychlorinated Biphenyls/blood/metabolism
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/blood/metabolism
MH  - Pregnancy
MH  - Sweden
MH  - Thyroid Hormones/*metabolism
MH  - Young Adult
EDAT- 2009/12/04 06:00
MHDA- 2010/03/05 06:00
CRDT- 2009/12/04 06:00
PHST- 2009/06/23 00:00 [received]
PHST- 2009/10/23 00:00 [revised]
PHST- 2009/11/06 00:00 [accepted]
PHST- 2009/12/04 06:00 [entrez]
PHST- 2009/12/04 06:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
AID - S0160-4120(09)00218-9 [pii]
AID - 10.1016/j.envint.2009.11.001 [doi]
PST - ppublish
SO  - Environ Int. 2010 Feb;36(2):180-7. doi: 10.1016/j.envint.2009.11.001. Epub 2009 
      Dec 1.