PMID- 19957783
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20221207
IS  - 1001-0939 (Print)
IS  - 1001-0939 (Linking)
VI  - 32
IP  - 6
DP  - 2009 Jun
TI  - [The relationship between monocyte chemoattractant protein-1 gene polymorphisms 
      and the susceptibility to pulmonary tuberculosis].
PG  - 454-6
AB  - OBJECTIVE: To explore the possible relationship between the -2518 A/G single 
      nucleotide polymorphisms in monocyte chemoattractant protein-1 (MCP-1) gene of 
      Chinese Han population and the susceptibility to pulmonary tuberculosis. METHODS: 
      A 1:1 matched case-control study was conducted from March 2008 to August 2008. 
      The - 2518 MCP-1 A/G polymorphisms were detected in 167 pairs of subjects by 
      reaction-restriction fragment length polymorphism (PCR-RLFP) technique. General 
      characteristics, current disease history, past medical history and related 
      environmental factors of tuberculosis were collected using a questionnaire 
      designed by ourselves. Univariate analyses and multivariate conditional logistic 
      analyses were conducted. RESULTS: The genotype frequencies of AA, GA and GG in 
      the case group and the control group were 21/167 (12.6%), 62/167 (37.1%), 84/167 
      (50.3%) and 42/167 (25.2%), 83/167 (49.7%), 42/167 (25.1%), respectively. There 
      was a significant difference in genotype frequencies between the case and the 
      control groups in the univariate analysis (chi2 = 24.041, P<0.01). The 
      significant association remained after adjusting environmental factors between 
      genotype GG (OR 1.989, 95% CI 1.154 - 3.428, chi2 = 6.124, P<0.05) and the 
      susceptibility to pulmonary tuberculosis. CONCLUSION: The -2518 MCP-1 GG genotype 
      might be associated with susceptibility to pulmonary tuberculosis in Chinese Han 
      population.
FAU - Yang, Ben-fu
AU  - Yang BF
AD  - Department of Epidemiology, School of Public Health, Jining Medical College, 
      Jining 272013, China.
FAU - Zhuang, Bin
AU  - Zhuang B
FAU - Li, Fang
AU  - Li F
FAU - Zhang, Chun-zhi
AU  - Zhang CZ
FAU - Song, Ai-qin
AU  - Song AQ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Jie He He Hu Xi Za Zhi
JT  - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal 
      of tuberculosis and respiratory diseases
JID - 8712226
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Tuberculosis, Pulmonary/*genetics
MH  - Young Adult
EDAT- 2009/12/05 06:00
MHDA- 2010/10/01 06:00
CRDT- 2009/12/05 06:00
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
PST - ppublish
SO  - Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jun;32(6):454-6.