PMID- 19957874
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20181201
IS  - 1077-5552 (Print)
IS  - 1077-5552 (Linking)
VI  - 15
DP  - 2009
TI  - Human T lymphocyte migration towards the supernatants of human rhinovirus 
      infected airway epithelial cells: influence of exercise and carbohydrate intake.
PG  - 127-44
AB  - Physical stress induces a marked redistribution of T lymphocytes that may be 
      influenced by carbohydrate (CHO) availability, yet the effect of these on T 
      lymphocyte migration towards infected tissue is unknown. Therefore, the aim of 
      this study was to determine the effect of strenuous exercise and CHO ingestion on 
      subsequent ex vivo lymphocyte migration towards the supernatants of a Human 
      Rhinovirus (HRV)-infected bronchial epithelial cell line. In a randomised, 
      cross-over, double-blind design, 7 trained males ran for 2 h at 60% VO2peak on 
      two occasions with regular ingestion of either a 6.4% w/v glucose and 
      maltodextrin solution (CHO trial) or placebo solution (PLA trial). Plasma glucose 
      concentration was higher on CHO than PLA after exercise (P<0.05). Migration of 
      CD4+ and CD8+ cells and their CD45RA+ and CD45RO+ subpopulations towards 
      supernatants from HRV-infected cells decreased following exercise (main effect 
      for exercise, P<0.01 for CD4+, CD4+CD45RA+ and CD4+CD45RO+; P<0.05 for CD8+, 
      CD8+CD45RA+ and CD8+CD45RO+). Migration of CD4+ cells and CD4+CD45RA+ cells was 
      approximately 35% and approximately 30% higher, respectively, on CHO than PLA at 
      1 h post-exercise (interaction, P<0.05 for both) and was higher on CHO than PLA 
      for all other subpopulations (P<0.05, main effect for trial). There was little 
      effect of exercise or CHO on migration of these cells towards uninfected 
      (control) cell supernatants or on the proportion of these cells within the 
      peripheral blood mononuclear cell population. The findings of this study suggest 
      that physical stress reduces T cell migration towards HRV-infected cell 
      supernatants and that ingestion of CHO can lessen this effect.
FAU - Bishop, Nicolette C
AU  - Bishop NC
AD  - School of Sport and Exercise Sciences, Loughborough University, Loughborough, 
      Leicestershire, UK. N.C.Bishop@lboro.ac.uk
FAU - Walker, Gary J
AU  - Walker GJ
FAU - Gleeson, Michael
AU  - Gleeson M
FAU - Wallace, Fiona A
AU  - Wallace FA
FAU - Hewitt, Colin R A
AU  - Hewitt CR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exerc Immunol Rev
JT  - Exercise immunology review
JID - 9505535
RN  - 0 (Blood Glucose)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Polysaccharides)
RN  - 7CVR7L4A2D (maltodextrin)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
RN  - IY9XDZ35W2 (Glucose)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Athletes
MH  - Blood Glucose/analysis
MH  - Cells, Cultured/drug effects/immunology/metabolism/virology
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - Cross-Over Studies
MH  - Culture Media, Conditioned/*pharmacology
MH  - Dietary Carbohydrates/pharmacology/*therapeutic use
MH  - Double-Blind Method
MH  - Epithelial Cells/immunology/metabolism/*virology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Glucose/pharmacology/therapeutic use
MH  - Humans
MH  - Hydrocortisone/blood/metabolism
MH  - Leukocyte Common Antigens/analysis
MH  - Leukocyte Count
MH  - Male
MH  - Neuroimmunomodulation/drug effects
MH  - Polysaccharides/pharmacology/therapeutic use
MH  - Rhinovirus/*immunology/physiology
MH  - Running/physiology
MH  - Stress, Physiological/immunology
MH  - T-Lymphocyte Subsets/*drug effects/immunology/physiology
EDAT- 2009/12/05 06:00
MHDA- 2010/01/13 06:00
CRDT- 2009/12/05 06:00
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PST - ppublish
SO  - Exerc Immunol Rev. 2009;15:127-44.