PMID- 19958239
OWN - NLM
STAT- MEDLINE
DCOM- 20100414
LR  - 20100208
IS  - 1651-1980 (Electronic)
IS  - 0036-5548 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Mar
TI  - The importance of pathogens in sepsis: Staphylococcus aureus story.
PG  - 172-6
LID - 10.3109/00365540903384141 [doi]
AB  - Different pathogens cause different outcomes for patients with sepsis. They 
      influence intensive care unit (ICU) mortality, ICU length of stay (ICU LOS) and 
      the need for mechanical ventilation (MV). We undertook a retrospective data-based 
      analysis over a 6-y period. Seventy-eight patients with methicillin-sensitive 
      Staphylococcus aureus (MSSA) and 74 patients with Escherichia coli (EC) sepsis 
      were included in the study. ICU mortality for the MSSA group was 32 (41.0%) vs 26 
      (35.1%) for the EC group (p = 0.506; OR 1.28, 95% CI 0.67-2.48). There was no 
      significant difference in ICU LOS (MSSA group: median 7.5, interquartile range 
      (IQR) 4-14 days and EC: median 5, IQR 3-13.5 days; p = 0.214). Need for MV in the 
      MSSA group was present in 45 (57.7%) patients vs 43 (58.1%) in the EC group. 
      Univariate analysis did not show that MSSA was independently associated with ICU 
      mortality (p = 0.506). Logistic regression analysis showed that after adjustment 
      for APACHE II, the chance of ICU death doubled in the MSSA group (odds ratio 
      2.166; 95% confidence interval 1.004-4.858). The odds for ICU admission were 8 
      times higher in MSSA patients. MSSA sepsis should be considered as an independent 
      factor for ICU mortality after adjustment for APACHE II.
FAU - Santini, Marija
AU  - Santini M
AD  - Intensive Care Unit, University Hospital for Infectious Disease Dr Fran 
      Mihaljevic, Zagreb, Croatia.
FAU - Kutlesa, Marko
AU  - Kutlesa M
FAU - Pangercic, Ana
AU  - Pangercic A
FAU - Barsic, Bruno
AU  - Barsic B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Infect Dis
JT  - Scandinavian journal of infectious diseases
JID - 0215333
SB  - IM
MH  - APACHE
MH  - Aged
MH  - Escherichia coli/*isolation & purification
MH  - Escherichia coli Infections/*mortality/pathology
MH  - Female
MH  - Humans
MH  - Length of Stay/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Respiration, Artificial/statistics & numerical data
MH  - Retrospective Studies
MH  - Sepsis/*microbiology/*mortality/pathology
MH  - Staphylococcal Infections/*mortality/pathology
MH  - Staphylococcus aureus/*isolation & purification
EDAT- 2009/12/05 06:00
MHDA- 2010/04/15 06:00
CRDT- 2009/12/05 06:00
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2010/04/15 06:00 [medline]
AID - 10.3109/00365540903384141 [doi]
PST - ppublish
SO  - Scand J Infect Dis. 2010 Mar;42(3):172-6. doi: 10.3109/00365540903384141.