PMID- 19960575
OWN - NLM
STAT- MEDLINE
DCOM- 20100216
LR  - 20220419
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 15
IP  - 45
DP  - 2009 Dec 7
TI  - Complete remission of gastric Burkitt's lymphoma after eradication of 
      Helicobacter pylori.
PG  - 5746-50
AB  - Burkitt's lymphoma is a highly aggressive non-Hodgkin lymphoma, often presenting 
      in extra-nodal sites. It generally has a poor spontaneous outcome and needs 
      aggressive treatment with systemic and intrathecal chemotherapy. Occurrence at 
      the gastric site is rare. We report the case of a 39-year old woman who presented 
      with a prominent ulcerated lesion of the antrum corresponding histologically to a 
      Burkitt's lymphoma associated with Helicobacter pylori (H pylori) infection. 
      Interphase fluorescence in situ hybridization (FISH) demonstrated c-MYC gene 
      rearrangement in tumour cells without BCL2 or BCL6 gene translocations. Ulcer 
      healing and tumour regression with a complete histological response were obtained 
      8 wk after H pylori eradication. In spite of this complete remission, taking into 
      account the high risk of recurrence, the patient received systemic and 
      intrathecal chemotherapy. Two years later, the patient remained in complete 
      remission. This is the first report of a gastric Burkitt's lymphoma responding to 
      H pylori eradication. These findings raise the question of the potential role of 
      H pylori in the pathogenesis of some gastric Burkitt's lymphomas, and show the 
      importance of searching for and eradicating the bacteria in combination with 
      conventional chemotherapy regimens.
FAU - Baumgaertner, Isabelle
AU  - Baumgaertner I
AD  - Department of Gastroenterology, AP-HP, Henri Mondor Hospital, Paris 12 
      University, Creteil, France. jean-charles.delchier@hmn.aphp.fr
FAU - Copie-Bergman, Christiane
AU  - Copie-Bergman C
FAU - Levy, Michael
AU  - Levy M
FAU - Haioun, Corinne
AU  - Haioun C
FAU - Charachon, Antoine
AU  - Charachon A
FAU - Baia, Maryse
AU  - Baia M
FAU - Sobhani, Iradj
AU  - Sobhani I
FAU - Delchier, Jean-Charles
AU  - Delchier JC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - D8TST4O562 (Pantoprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use
MH  - Adult
MH  - Anti-Ulcer Agents/therapeutic use
MH  - *Burkitt Lymphoma/drug therapy/microbiology/pathology
MH  - Female
MH  - Gastric Mucosa/microbiology/pathology
MH  - Helicobacter Infections/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Pantoprazole
MH  - Remission Induction
MH  - *Stomach Neoplasms/drug therapy/microbiology/pathology
MH  - Treatment Outcome
PMC - PMC2789231
EDAT- 2009/12/05 06:00
MHDA- 2010/02/17 06:00
PMCR- 2009/12/07
CRDT- 2009/12/05 06:00
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2010/02/17 06:00 [medline]
PHST- 2009/12/07 00:00 [pmc-release]
AID - 10.3748/wjg.15.5746 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2009 Dec 7;15(45):5746-50. doi: 10.3748/wjg.15.5746.