PMID- 19960706
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20190513
IS  - 0022-2585 (Print)
IS  - 0022-2585 (Linking)
VI  - 46
IP  - 6
DP  - 2009 Nov
TI  - Lymphadenopathy and expression of nodal mast cells and eosinophils in the myiasis 
      by human bot fly.
PG  - 1514-8
AB  - Wistar rats (Rattus norvegicus) infested with Dermatobia hominis (L. Jr., 1781) 
      had their axillary lymph nodes removed and histopathologically processed. 
      Follicular hyperplasia in the germinal center was noted from 2 d postinfestation 
      (dpi), exhibiting a high number of centerblasts, mitotic and apoptotic cells, and 
      a thin parafollicular area. The paracortex showed hyperplasia rich in dendritic 
      cells, immunoblasts, and endothelial venules, with diapedesis seen from 4 dpi 
      onward. Hyperplasia of the medullar sinus also was first observed at this point, 
      as well as dilated lymphatic sinus, lymph, macrophages, neutrophils, mast cells, 
      and eosinophils. Medullar strings were expanded and filled with immunoblasts, 
      mitotic cells, and plasmocytes. Lymphadenitis was not observed. The expression of 
      mast cells was similar for both myiasis-affected and control rats but increased 
      significantly (mastocytosis) at 7 and 15 d postlarval emergence (dple). 
      Eosinophilia was observed at 4, 10, 15, 20, and 28 dpi as well as at 2, 7, and 15 
      dple, particularly on the last three observations of dpi and the earliest dple. 
      This experimental approach allowed progressive tissue reactions in the lymph 
      nodes to be monitored during myiasis, particularly those involving mast cells and 
      eosinophils. These reactions abated and complete repair was observed at 60 dple.
FAU - Cardoso, P J G
AU  - Cardoso PJ
AD  - Department of Parasitology, Institute of Biological Sciences, Federal University 
      of Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil.
FAU - Leite, V H R
AU  - Leite VH
FAU - Leite, L H R
AU  - Leite LH
FAU - Leite, A C R
AU  - Leite AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Entomol
JT  - Journal of medical entomology
JID - 0375400
SB  - IM
MH  - Animals
MH  - Diptera/*growth & development
MH  - Eosinophils/immunology/*pathology
MH  - Lymph Nodes/immunology/pathology
MH  - Lymphatic Diseases/immunology/*parasitology
MH  - Male
MH  - Mast Cells/immunology/*pathology
MH  - Myiasis/immunology/*pathology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2009/12/08 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - 10.1603/033.046.0640 [doi]
PST - ppublish
SO  - J Med Entomol. 2009 Nov;46(6):1514-8. doi: 10.1603/033.046.0640.