PMID- 19961866
OWN - NLM
STAT- MEDLINE
DCOM- 20100609
LR  - 20100224
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 48
IP  - 4
DP  - 2010 Mar
TI  - An epistasis effect of functional variants on the BDNF and DRD2 genes modulates 
      gray matter volume of the anterior cingulate cortex in healthy humans.
PG  - 1016-21
LID - 10.1016/j.neuropsychologia.2009.11.027 [doi]
AB  - Recent evidence suggests that mesolimbic dopaminergic pathways are regulated by 
      the brain derived neurotrophic factor (BDNF). The present study shows that the 
      prominent single nucleotide polymorphisms (SNPs) BDNF Val66Met and DRD2 Taq 
      Ia/ANKK1 exert an epistasis effect on the anterior cingulate cortex (ACC) in 161 
      healthy Caucasian participants. Carriers with at least one 66Met allele (Val66Met 
      and Met66Met) of the BDNF SNP and one A1 allele (A1/A1 and A1/A2) of the DRD2 SNP 
      are associated with the lowest gray matter volume of the ACC in the current 
      sample. As the smaller gray matter volume of the ACC has been associated with 
      addiction before, this study yields evidence that especially carriers of both 
      allele variants that have been associated with addiction and other 
      psychopathological disorders before might have an increased risk to develop 
      psychiatric symptoms under adverse environmental conditions.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Montag, Christian
AU  - Montag C
AD  - Department of Psychology, University of Bonn, Germany. 
      christian.montag@uni-bonn-diff.de
FAU - Weber, Bernd
AU  - Weber B
FAU - Jentgens, Eva
AU  - Jentgens E
FAU - Elger, Christian
AU  - Elger C
FAU - Reuter, Martin
AU  - Reuter M
LA  - eng
PT  - Journal Article
DEP - 20091202
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Dopamine D2)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Gyrus Cinguli/*anatomy & histology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Dopamine D2/*genetics
EDAT- 2009/12/08 06:00
MHDA- 2010/06/10 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/10/16 00:00 [received]
PHST- 2009/11/26 00:00 [revised]
PHST- 2009/11/27 00:00 [accepted]
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/06/10 06:00 [medline]
AID - S0028-3932(09)00459-X [pii]
AID - 10.1016/j.neuropsychologia.2009.11.027 [doi]
PST - ppublish
SO  - Neuropsychologia. 2010 Mar;48(4):1016-21. doi: 
      10.1016/j.neuropsychologia.2009.11.027. Epub 2009 Dec 2.