PMID- 19964070
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20240129
IS  - 2375-7477 (Print)
IS  - 2375-7477 (Linking)
VI  - 2009
DP  - 2009
TI  - Nonlinear model of single hippocampal neurons with dynamical thresholds.
PG  - 3330-4
LID - 10.1109/IEMBS.2009.5333275 [doi]
AB  - Neurons transform a series of presynaptic spikes into a series of postsynaptic 
      spikes through a number of nonlinear mechanisms. A nonlinear model with a 
      dynamical threshold was built using a Volterra Laguerre kernel method to 
      characterize the spike train to spike train transformations of hippocampal CA1 
      pyramidal neurons. Inputs of the model were broadband Poisson random impulse 
      trains with a 2 Hz mean frequency, and outputs of the model were the 
      corresponding evoked post-synaptic potential (PSP) and spike train data recorded 
      from CA1 cell bodies using a whole-cell recording technique. The model consists 
      of four major components, i.e., feedforward kernels representing the 
      transformation of presynaptic spikes to PSPs; a dynamical threshold kernel 
      determining threshold value based on output inter-spike-intervals (ISIs); a spike 
      detector; and a feedback kernel representing the spike-triggered 
      after-potentials.
FAU - Lu, Ude
AU  - Lu U
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles, CA 90089, USA. ulu@ usc.edu
FAU - Song, Dong
AU  - Song D
FAU - Berger, Theodore W
AU  - Berger TW
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Action Potentials
MH  - Algorithms
MH  - Animals
MH  - CA1 Region, Hippocampal/*pathology
MH  - Electrophysiology/methods
MH  - Hippocampus/*pathology
MH  - Male
MH  - Models, Neurological
MH  - Neurons/*physiology
MH  - Poisson Distribution
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Processing, Computer-Assisted
MH  - Synapses/pathology
MH  - Synaptic Transmission
EDAT- 2009/12/08 06:00
MHDA- 2010/04/23 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - 10.1109/IEMBS.2009.5333275 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:3330-4. doi: 
      10.1109/IEMBS.2009.5333275.