PMID- 19964847
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20200928
IS  - 2375-7477 (Print)
IS  - 2375-7477 (Linking)
VI  - 2009
DP  - 2009
TI  - On the possibility to detect lipid in atherosclerotic plaques using intravascular 
      photoacoustic imaging.
PG  - 4767-70
LID - 10.1109/IEMBS.2009.5334213 [doi]
AB  - Large lipid core is common in rupture-prone atherosclerotic plaques. Detection of 
      the location and distribution of lipid in the atherosclerotic plaques can greatly 
      benefit the diagnosis and treatment of vulnerable plaques. Recently introduced 
      intravascular photoacoustic (IVPA) imaging - a technique to image the optical 
      absorption property of tissue - can be used to detect and differentiate 
      atherosclerotic plaques. In this work, we further investigated the ability of 
      using spectroscopic IVPA imaging to visualize the lipid in atherosclerotic 
      plaques. IVPA imaging was performed on an ex-vivo rabbit aorta in the 1200 - 1230 
      nm wavelength range. In the lipid-rich plaques, the photoacoustic signal strength 
      within this spectral range behaved similar to the optical absorption spectrum of 
      fatty tissue. To distinguish lipid from other types of tissue, correlation 
      analysis was used. Specifically, intraclass correlation between the IVPA signals 
      and the absorption spectrum of lipid reconstructed from multi-wavelength IVPA 
      images was conducted on a pixel-by-pixel basis. The resulted correlation map 
      showed the distribution of lipid in the atherosclerotic plaques. The distribution 
      of lipid is further confirmed by histopathological analysis of tissue. The 
      results of our study suggest that spectroscopic IVPA imaging, together with 
      correlation analysis, may be used to detect lipid in atherosclerotic plaques.
FAU - Wang, Bo
AU  - Wang B
AD  - Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 
      78712, USA.
FAU - Su, Jimmy
AU  - Su J
FAU - Amirian, James
AU  - Amirian J
FAU - Litovsky, Silvio H
AU  - Litovsky SH
FAU - Smalling, Richard
AU  - Smalling R
FAU - Emelianov, Stanislav
AU  - Emelianov S
LA  - eng
GR  - HL084076/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*diagnosis/pathology
MH  - Diagnostic Imaging/*methods
MH  - Microscopy, Acoustic/*methods
MH  - Rabbits
MH  - Ultrasonography, Interventional/methods
EDAT- 2009/12/08 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.1109/IEMBS.2009.5334213 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4767-70. doi: 
      10.1109/IEMBS.2009.5334213.