PMID- 19965844
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20171114
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 81
IP  - 6
DP  - 2010 Jun
TI  - Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya 
      disease.
PG  - 673-8
LID - 10.1136/jnnp.2009.191817 [doi]
AB  - OBJECTIVE: To document the expression patterns of various matrixins, cytokines 
      and angiogenic factors in plasma to assess their involvement in the pathogenesis 
      of moyamoya disease (MMD). METHODS: This study included plasma samples from 20 
      MMD patients and nine healthy individuals. The plasma concentration of five 
      matrix metalloproteinases (MMP-1, MMP-2, MMP-3, MMP-9, MMP-12), monocyte 
      chemoattractant protein-1 (MCP-1), resistin, three interleukins (IL-1beta, IL-6, 
      IL-8), tumour necrosis factor-alpha, vascular endothelial growth factor (VEGF), 
      platelet-derived growth factor BB (PDGF-BB) and basic fibroblast growth factor 
      was determined using multianalyte profiling systems. The concentration of the 
      tissue inhibitors of metalloproteinase (TIMP-1 and TIMP-2) was measured using 
      ELISA. Gelatin zymography for MMP-2 and MMP-9 was also performed. RESULTS: MMD 
      patients exhibited significantly higher plasma concentrations of MMP-9, MCP-1, 
      IL-1beta, VEGF and PDGF-BB, and lower plasma concentrations of MMP-3, TIMP-1 and 
      TIMP-2 compared with healthy controls. Significant correlations were found among 
      MMP-9, MCP-1, VEGF, PDGF-BB and TIMP-2 in MMD patients. CONCLUSION: There were 
      distinctive expression patterns of matrixins, cytokines and angiogenic factors in 
      MMD patients, which seemed to correlate with disease pathogenesis. The balance 
      between MMPs and TIMPs was disrupted in MMD and correlated with disease 
      pathogenesis. Increased plasma levels of MCP-1 and VEGF in MMD patients may play 
      a role in the recruitment of vascular progenitor cells and in the formation of 
      collateral vessels.
FAU - Kang, Hyun-Seung
AU  - Kang HS
AD  - Department of Neurosurgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Kim, Jin Hyun
AU  - Kim JH
FAU - Phi, Ji Hoon
AU  - Phi JH
FAU - Kim, Young-Yim
AU  - Kim YY
FAU - Kim, Jeong Eun
AU  - Kim JE
FAU - Wang, Kyu-Chang
AU  - Wang KC
FAU - Cho, Byung-Kyu
AU  - Cho BK
FAU - Kim, Seung-Ki
AU  - Kim SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091203
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cytokines)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Lymphokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor
MH  - Cytokines/*blood
MH  - Endothelial Growth Factors/*blood
MH  - Female
MH  - Fibroblast Growth Factor 2/*blood
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Lymphokines/blood
MH  - Male
MH  - Matrix Metalloproteinases/*blood
MH  - Moyamoya Disease/*blood
MH  - Vascular Endothelial Growth Factor A/*blood
MH  - Vascular Endothelial Growth Factors/*blood
EDAT- 2009/12/08 06:00
MHDA- 2010/06/24 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
AID - jnnp.2009.191817 [pii]
AID - 10.1136/jnnp.2009.191817 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2010 Jun;81(6):673-8. doi: 
      10.1136/jnnp.2009.191817. Epub 2009 Dec 3.