PMID- 19966382
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220331
IS  - 1748-605X (Electronic)
IS  - 1748-6041 (Linking)
VI  - 4
IP  - 6
DP  - 2009 Dec
TI  - Time-of-flight secondary ion mass spectrometry study on the distribution of 
      alendronate sodium in drug-loaded ultra-high molecular weight polyethylene.
PG  - 065008
LID - 10.1088/1748-6041/4/6/065008 [doi]
AB  - The aim of this study was to investigate the drug distribution in ultra-high 
      molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), 
      which was developed to treat particle-induced osteolysis after artificial joint 
      replacements, since the drug distribution in UHMWPE could play a key role in 
      controlling drug release. A mixture of UHMWPE powder and ALN was dried and hot 
      pressed to prepare UHMWPE loaded with ALN (UHMWPE-ALN). Fourier transform 
      infrared spectroscopy analysis demonstrated that the hot press had no effect on 
      the functional groups of ALN in UHMWPE-ALN. X-ray diffraction indicated that 
      there was no phase change of the UHMWPE after hot pressing. Time-of-flight 
      secondary ion mass spectrometry (ToF-SIMS) spectra revealed the existence of 
      characteristic elements and functional groups from ALN in UHMWPE-ALN, such as 
      Na+, C3H8N+, PO3(-) and PO3H(-). In addition, SIMS images suggested that ALN did 
      not agglomerate in UHMWPE-ALN. A small punch test and hardness test were carried 
      out and the results indicated that ALN did not affect the mechanical properties 
      at the present content level. The present study demonstrated that it was feasible 
      to fabricate the un-agglomerated distributed drug in UHMWPE with good mechanical 
      properties. This ALN loaded UHMWPE would have potential application in clinics.
FAU - Liu, Xiaomin
AU  - Liu X
AD  - Key Lab of Advanced Technologies of Materials, Ministry of Education, School of 
      Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, 
      People's Republic of China.
FAU - Qu, Shuxin
AU  - Qu S
FAU - Lu, Xiong
AU  - Lu X
FAU - Ge, Xiang
AU  - Ge X
FAU - Leng, Yang
AU  - Leng Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biomed Mater
JT  - Biomedical materials (Bristol, England)
JID - 101285195
RN  - 0 (Biocompatible Materials)
RN  - 0 (Ions)
RN  - 0 (Polyethylenes)
RN  - 0 (Powders)
RN  - 0 (ultra-high molecular weight polyethylene)
RN  - X1J18R4W8P (Alendronate)
SB  - IM
MH  - Alendronate/*chemistry
MH  - Arthroplasty, Replacement/*instrumentation/methods
MH  - Biocompatible Materials/*chemistry
MH  - Drug Delivery Systems
MH  - Hardness Tests
MH  - Humans
MH  - Ions
MH  - Mass Spectrometry/*methods
MH  - Materials Testing
MH  - Osteolysis/metabolism
MH  - Polyethylenes/*chemistry
MH  - Powders
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Stress, Mechanical
MH  - X-Ray Diffraction
EDAT- 2009/12/08 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S1748-6041(09)23502-9 [pii]
AID - 10.1088/1748-6041/4/6/065008 [doi]
PST - ppublish
SO  - Biomed Mater. 2009 Dec;4(6):065008. doi: 10.1088/1748-6041/4/6/065008.