PMID- 19967051
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2093-3827 (Electronic)
IS  - 1226-4512 (Print)
IS  - 1226-4512 (Linking)
VI  - 12
IP  - 4
DP  - 2008 Aug
TI  - Synergistic efficacy of concurrent treatment with cilostazol and probucol on the 
      suppression of reactive oxygen species and inflammatory markers in cultured human 
      coronary artery endothelial cells.
PG  - 165-70
LID - 10.4196/kjpp.2008.12.4.165 [doi]
AB  - In the present study, we aimed to identify the synergistic effects of concurrent 
      treatment of low concentrations of cilostazol and probucol to inhibit the 
      oxidative stress with suppression of inflammatory markers in the cultured human 
      coronary artery endothelial cells (HCAECs). Combination of cilostazol (0.3~3 
      microM) with probucol (0.03~0.3 microM) significantly suppressed 
      TNF-alpha-stimulated NAD(P)H-dependent superoxide, lipopolysaccharide 
      (LPS)-induced intracellular reactive oxygen species (ROS) production and 
      TNF-alpha release in comparison with probucol or cilostazol alone. The 
      combination of cilostazol (0.3~3 microM) with probucol (0.1~0.3 microM) inhibited 
      the expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte 
      chemoattractant protein-1 (MCP-1) more significantly than did the monotherapy 
      with either probucol or cilostazol. In line with these results, combination 
      therapy significantly suppressed monocyte adhesion to endothelial cells. Taken 
      together, it is suggested that the synergistic effectiveness of the combination 
      therapy with cilostazol and probucol may provide a beneficial therapeutic window 
      in preventing atherosclerosis and protecting from cerebral ischemic injury.
FAU - Park, So Youn
AU  - Park SY
AD  - Department of Pharmacology Pusan National University College of Medicine, Busan 
      602-739, Korea.
FAU - Lee, Jeong Hyun
AU  - Lee JH
FAU - Shin, Hwa Kyoung
AU  - Shin HK
FAU - Kim, Chi Dae
AU  - Kim CD
FAU - Lee, Won Suk
AU  - Lee WS
FAU - Rhim, Byung Yong
AU  - Rhim BY
FAU - Shin, Yung Woo
AU  - Shin YW
FAU - Hong, Ki Whan
AU  - Hong KW
LA  - eng
PT  - Journal Article
DEP - 20080831
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC2788631
OTO - NOTNLM
OT  - Cilostazol
OT  - Endothelial cells
OT  - MCP-1
OT  - Monocyte adhesion
OT  - Probucol
OT  - Synergism
OT  - VCAM-1
EDAT- 2008/08/01 00:00
MHDA- 2008/08/01 00:01
PMCR- 2008/08/01
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2008/08/01 00:00 [pubmed]
PHST- 2008/08/01 00:01 [medline]
PHST- 2008/08/01 00:00 [pmc-release]
AID - 10.4196/kjpp.2008.12.4.165 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2008 Aug;12(4):165-70. doi: 
      10.4196/kjpp.2008.12.4.165. Epub 2008 Aug 31.