PMID- 19996415
OWN - NLM
STAT- MEDLINE
DCOM- 20100216
LR  - 20220309
IS  - 1941-3297 (Electronic)
IS  - 1941-3289 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Jan
TI  - Clinical outcome 2 years after intracoronary administration of bone 
      marrow-derived progenitor cells in acute myocardial infarction.
PG  - 89-96
LID - 10.1161/CIRCHEARTFAILURE.108.843243 [doi]
AB  - BACKGROUND: The aim of this study was to investigate the clinical outcome 2 years 
      after intracoronary administration of autologous progenitor cells in patients 
      with acute myocardial infarction (AMI). METHODS AND RESULTS: Using a 
      double-blind, placebo-controlled, multicenter trial design, we randomized 204 
      patients with successfully reperfused AMI to receive intracoronary infusion of 
      bone marrow-derived progenitor cells (BMC) or placebo medium into the infarct 
      artery 3 to 7 days after successful infarct reperfusion therapy. At 2 years, the 
      cumulative end point of death, myocardial infarction, or necessity for 
      revascularization was significantly reduced in the BMC group compared with 
      placebo (hazard ratio, 0.58; 95% CI, 0.36 to 0.94; P=0.025). Likewise, the 
      combined end point death and recurrence of myocardial infarction and 
      rehospitalization for heart failure, reflecting progression toward heart failure, 
      was significantly reduced in the BMC group (hazard ratio, 0.26; 95% CI, 0.085 to 
      0.77; P=0.015). Intracoronary administration of BMC remained a significant 
      predictor of a favorable clinical outcome by Cox regression analysis when 
      adjusted for classical predictors of poor outcome after AMI. There was no 
      evidence of increased restenosis or atherosclerotic disease progression after BMC 
      therapy nor any evidence of increased ventricular arrhythmias or neoplasms. In 
      addition, regional left ventricular contractility of infarcted segments, as 
      assessed by MRI in a subgroup of patients at 2-year follow-up, was significantly 
      higher in the BMC group compared with the placebo group (P<0.001). CONCLUSIONS: 
      Intracoronary administration of BMC is associated with a significant reduction of 
      the occurrence of major adverse cardiovascular events maintained for 2 years 
      after AMI. Moreover, functional improvements after BMC therapy may persist for at 
      least 2 years. Larger studies focusing on clinical event rates are warranted to 
      confirm the effects of BMC administration on mortality and progression of heart 
      failure in patients with AMIs. Clinical Trial Registration- clinicaltrials.gov. 
      Identifier: NCT00279175.
FAU - Assmus, Birgit
AU  - Assmus B
AD  - J W Goethe Universitat, Division of Cardiology, Frankfurt, Germany.
FAU - Rolf, Andreas
AU  - Rolf A
FAU - Erbs, Sandra
AU  - Erbs S
FAU - Elsasser, Albrecht
AU  - Elsasser A
FAU - Haberbosch, Werner
AU  - Haberbosch W
FAU - Hambrecht, Rainer
AU  - Hambrecht R
FAU - Tillmanns, Harald
AU  - Tillmanns H
FAU - Yu, Jiangtao
AU  - Yu J
FAU - Corti, Roberto
AU  - Corti R
FAU - Mathey, Detlef G
AU  - Mathey DG
FAU - Hamm, Christian W
AU  - Hamm CW
FAU - Suselbeck, Tim
AU  - Suselbeck T
FAU - Tonn, Torsten
AU  - Tonn T
FAU - Dimmeler, Stefanie
AU  - Dimmeler S
FAU - Dill, Thorsten
AU  - Dill T
FAU - Zeiher, Andreas M
AU  - Zeiher AM
FAU - Schachinger, Volker
AU  - Schachinger V
CN  - REPAIR-AMI Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00279175
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20091208
PL  - United States
TA  - Circ Heart Fail
JT  - Circulation. Heart failure
JID - 101479941
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Coronary Vessels
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*surgery
MH  - *Stem Cell Transplantation
MH  - Stem Cells
MH  - Treatment Outcome
EDAT- 2009/12/10 06:00
MHDA- 2010/02/17 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/02/17 06:00 [medline]
AID - CIRCHEARTFAILURE.108.843243 [pii]
AID - 10.1161/CIRCHEARTFAILURE.108.843243 [doi]
PST - ppublish
SO  - Circ Heart Fail. 2010 Jan;3(1):89-96. doi: 10.1161/CIRCHEARTFAILURE.108.843243. 
      Epub 2009 Dec 8.