PMID- 19997942
OWN - NLM
STAT- MEDLINE
DCOM- 20100702
LR  - 20220409
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Linking)
VI  - 45
IP  - 4
DP  - 2010 Apr
TI  - The prokinetic effect of mosapride citrate combined with omeprazole therapy 
      improves clinical symptoms and gastric emptying in PPI-resistant NERD patients 
      with delayed gastric emptying.
PG  - 413-21
LID - 10.1007/s00535-009-0173-0 [doi]
AB  - BACKGROUND: Previous studies have shown that non-erosive reflux disease (NERD) 
      patients are less sensitive to proton pump inhibitor (PPI) treatment than 
      patients with erosive reflux disease. The aim of this study was to investigate 
      whether treatment with prokinetics in addition to omeprazole therapy would 
      improve clinical symptoms, gastric emptying and esophageal peristalsis in 
      PPI-resistant NERD patients with or without delayed gastric emptying. METHODS: 
      Subjects were 64 consecutive patients presenting with typical symptoms of 
      PPl-resistant NERD (n = 44) and 20 healthy volunteers. PPI-resistant NERD 
      patients underwent mosapride citrate (15 mg/day) and omeprazole (20 mg/day) 
      co-therapy for 12 weeks. We evaluated the clinical symptoms as well as gastric 
      emptying and esophageal manometry before and after combined therapy. We measured 
      both acylated- and des-acylated plasma ghrelin levels by the ELISA method. The 
      primary endopoint was to investigate whether co-administration of mosapride 
      citrate and omeprazole would improve clinical symptoms and gastric emptying in 
      PPI-resistant NERD patients with delayed gastric emptying. RESULTS: T (max) value 
      in PPI-resistant NERD patients was significantly higher than in healthy 
      volunteers. Combination therapy with the prokinetic agent mosapride citrate and 
      omeprazole significantly improved reflux symptoms and T (max) value in T (max) > 
      65 min NERD patients. Co-therapy also significantly reduced des-acylated-ghrelin 
      levels in NERD patients with delayed gastric emptying. CONCLUSIONS: 
      Administration of mosapride citrate in addition to omeprazole improved 
      gastro-esophageal reflux and gastric emptying in PPI-resistant NERD patients with 
      delayed gastric emptying.
FAU - Futagami, Seiji
AU  - Futagami S
AD  - Division of Gastroenterology, Department of Internal Medicine, Nippon Medical 
      School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. seiji.futagami@gmail.com
FAU - Iwakiri, Katsuhiko
AU  - Iwakiri K
FAU - Shindo, Tomotaka
AU  - Shindo T
FAU - Kawagoe, Tetsuro
AU  - Kawagoe T
FAU - Horie, Akane
AU  - Horie A
FAU - Shimpuku, Mayumi
AU  - Shimpuku M
FAU - Tanaka, Yuriko
AU  - Tanaka Y
FAU - Kawami, Noriyuki
AU  - Kawami N
FAU - Gudis, Katya
AU  - Gudis K
FAU - Sakamoto, Choitsu
AU  - Sakamoto C
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091210
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Benzamides)
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Ghrelin)
RN  - 0 (Morpholines)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (ghrelin, des-n-octanoyl)
RN  - I8MFJ1C0BY (mosapride)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Adult
MH  - Anti-Ulcer Agents/administration & dosage/therapeutic use
MH  - Benzamides/administration & dosage/*therapeutic use
MH  - Case-Control Studies
MH  - Double-Blind Method
MH  - Drug Resistance
MH  - Drug Therapy, Combination
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Gastric Emptying
MH  - Gastroesophageal Reflux/*drug therapy/physiopathology
MH  - Gastrointestinal Agents/administration & dosage/therapeutic use
MH  - Ghrelin/blood
MH  - Humans
MH  - Male
MH  - Manometry/methods
MH  - Middle Aged
MH  - Morpholines/administration & dosage/*therapeutic use
MH  - Omeprazole/administration & dosage/*therapeutic use
MH  - Proton Pump Inhibitors/administration & dosage/therapeutic use
EDAT- 2009/12/10 06:00
MHDA- 2010/07/03 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/01/16 00:00 [received]
PHST- 2009/11/11 00:00 [accepted]
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/07/03 06:00 [medline]
AID - 10.1007/s00535-009-0173-0 [doi]
PST - ppublish
SO  - J Gastroenterol. 2010 Apr;45(4):413-21. doi: 10.1007/s00535-009-0173-0. Epub 2009 
      Dec 10.