PMID- 19998243
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20131121
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 118
IP  - 9
DP  - 2010 Oct
TI  - The effect of metformin treatment for 2 years without caloric restriction on 
      endocrine and metabolic parameters in women with polycystic ovary syndrome.
PG  - 633-7
LID - 10.1055/s-0029-1237705 [doi]
AB  - INTRODUCTION: The aim of this study was to evaluate long-term changes in 
      endocrine and metabolic parameters and body mass index in women with polycystic 
      ovary syndrome (PCOS) who were treated with metformin over 2 years without 
      caloric restriction. MATERIAL AND METHODS: Twenty-six obese women with PCOS were 
      treated with metformin over 2 years without caloric restriction. Clinical, 
      metabolic and endocrine parameters and the body mass index were measured and an 
      oral glucose tolerance test was carried out to calculate insulin resistance 
      indices at the beginning and at the follow-up after 2 years. The Homeostatic 
      Model for Assessment of Insulin Resistance (HOMA-IR) was calculated. RESULTS: No 
      significant changes in body mass index or HOMA-IR were observed. However, a 
      significant decrease in fasting and 2-h insulin levels was observed. Women showed 
      a significant increase in sex hormone-binding globulin (SHBG) levels, while total 
      testosterone (TT) levels and the free androgen index decreased significantly. 
      Furthermore a significant decrease in hirsutism was observed. There was a 
      decrease in cholesterol and an increase in high-density lipoprotein. CONCLUSIONS: 
      Long-term treatment with metformin in women with PCOS appears to reduce androgen 
      excess due to increased SHBG and decreased TT levels resulting in improvement of 
      hirsutism as a clinical sign of androgen excess. Furthermore a significant 
      decrease in fasting and 2-h insulin levels and slightly improved insulin 
      resistance indices were observed.
CI  - (c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart . New York.
FAU - Oppelt, P G
AU  - Oppelt PG
AD  - Department of Obstetrics and Gynecology, University Hospital Erlangen, Erlangen, 
      Germany.
FAU - Mueller, A
AU  - Mueller A
FAU - Jentsch, K
AU  - Jentsch K
FAU - Kronawitter, D
AU  - Kronawitter D
FAU - Reissmann, C
AU  - Reissmann C
FAU - Dittrich, R
AU  - Dittrich R
FAU - Beckmann, M W
AU  - Beckmann MW
FAU - Cupisti, S
AU  - Cupisti S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091208
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Caloric Restriction
MH  - Drug Administration Schedule
MH  - Endocrine System/*drug effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage/pharmacology/therapeutic use
MH  - Insulin/metabolism
MH  - Insulin Resistance
MH  - Metformin/administration & dosage/*pharmacology/therapeutic use
MH  - Obesity/blood/complications/drug therapy/metabolism
MH  - Polycystic Ovary Syndrome/blood/complications/drug therapy/*metabolism
MH  - Sex Hormone-Binding Globulin/metabolism
MH  - Testosterone/blood/metabolism
MH  - Time Factors
EDAT- 2009/12/10 06:00
MHDA- 2011/02/03 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1055/s-0029-1237705 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2010 Oct;118(9):633-7. doi: 10.1055/s-0029-1237705. 
      Epub 2009 Dec 8.