PMID- 19998324
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20240109
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Print)
IS  - 0951-418X (Linking)
VI  - 24
IP  - 7
DP  - 2010 Jul
TI  - Pharmacology and immunological actions of a herbal medicine ASHMI on allergic 
      asthma.
PG  - 1047-55
LID - 10.1002/ptr.3077 [doi]
AB  - Allergic asthma is a chronic and progressive inflammatory disease for which there 
      is no satisfactory treatment. Studies reported tolerability and efficacy of an 
      anti-asthma herbal medicine intervention (ASHMI) for asthma patients, developed 
      from traditional Chinese medicine. To investigate the pharmacological actions of 
      ASHMI on early- and late-phase airway responses (EAR and LAR), Ovalbumin 
      (OVA)-sensitized mice received 6 weeks of ASHMI treatment beginning 24 h 
      following the first intratracheal OVA challenge. EAR were determined 30 min 
      following the fourth challenge and LAR 48 h following the last challenge. ASHMI 
      effects on cytokine secretion, murine tracheal ring contraction and human 
      bronchial smooth muscle cell prostaglandin (PG) production were also 
      determined.ASHMI abolished EAR, which was associated with significantly reduced 
      histamine, leukotriene C4, and OVA-specific IgE levels, as well as LAR, which was 
      associated with significantly reduced bronchoalveolar lavage fluid (BALF) 
      eosinophils, decreased airway remodeling, and lower Th2 cytokine levels in BALF 
      and splenocyte cultures. Furthermore, ASHMI inhibited contraction of murine 
      tracheal rings and increased production of the potent smooth muscle relaxer 
      PGI(2). ASHMI abrogation of allergic airway responses is associated with broad 
      effects on asthma pathological mechanisms.
FAU - Zhang, Tengfei
AU  - Zhang T
AD  - Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA.
FAU - Srivastava, Kamal
AU  - Srivastava K
FAU - Wen, Ming-Chun
AU  - Wen MC
FAU - Yang, Nan
AU  - Yang N
FAU - Cao, Jing
AU  - Cao J
FAU - Busse, Paula
AU  - Busse P
FAU - Birmingham, Neil
AU  - Birmingham N
FAU - Goldfarb, Joseph
AU  - Goldfarb J
FAU - Li, Xiu-Min
AU  - Li XM
LA  - eng
GR  - P01 AT002647/AT/NCCIH NIH HHS/United States
GR  - 1P01 AT002644725-01/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Prostaglandins)
RN  - 2CU6TT9V48 (Leukotriene C4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Airway Remodeling
MH  - Animals
MH  - Anti-Asthmatic Agents/*pharmacology
MH  - Asthma/*drug therapy/immunology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Chromatography, High Pressure Liquid
MH  - Cytokines/metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Eosinophils/drug effects/immunology
MH  - Histamine/blood
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - In Vitro Techniques
MH  - Leukotriene C4/blood
MH  - Lung/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Structure
MH  - Myocytes, Smooth Muscle/drug effects
MH  - Ovalbumin/pharmacology
MH  - Prostaglandins/metabolism
MH  - Trachea/drug effects
PMC - PMC4706449
MID - NIHMS744721
EDAT- 2009/12/10 06:00
MHDA- 2010/09/08 06:00
PMCR- 2016/01/08
CRDT- 2009/12/10 06:00
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
PHST- 2016/01/08 00:00 [pmc-release]
AID - 10.1002/ptr.3077 [doi]
PST - ppublish
SO  - Phytother Res. 2010 Jul;24(7):1047-55. doi: 10.1002/ptr.3077.