PMID- 20003135
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 75
IP  - 2
DP  - 2010 Feb
TI  - Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian 
      populations.
PG  - 151-8
LID - 10.1111/j.1399-0039.2009.01417.x [doi]
AB  - This is the first report of high-resolution human leukocyte antigen (HLA) typing 
      in four indigenous groups in Malaysia. A total of 99 normal, healthy participants 
      representing the Negrito (Jehai and Kensiu), Proto-Malay (Temuan) and a native 
      group of Borneo (Bidayuh) were typed for HLA-A, -B, -DRB1 and -DQB1 genes using 
      sequence-based typing. Eleven HLA-A, 26 HLA-B, 16 HLA-DRB1 and 14 HLA-DQB1 
      alleles were detected, including a new allele, HLA-B*3589 in the Jehai. Highly 
      frequent alleles were A*2407, B*1513, B*1801, DRB1*0901, DRB1*1202, DRB1*1502, 
      DQB1*0303 and DQB1*0502. Principal component analysis based on high-resolution 
      HLA-A, -B and -DRB1 allele frequencies showed close affinities among all four 
      groups, including the Negritos, with other Southeast Asian populations. These 
      results showed the scope of HLA diversity in these indigenous minority groups and 
      may prove beneficial for future disease association, anthropological and forensic 
      studies.
FAU - Jinam, T A
AU  - Jinam TA
AD  - Division of Population Genetics, National Institute of Genetics, Mishima, Japan.
FAU - Saitou, N
AU  - Saitou N
FAU - Edo, J
AU  - Edo J
FAU - Mahmood, A
AU  - Mahmood A
FAU - Phipps, M E
AU  - Phipps ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091214
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*12:02 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - HLA Antigens/genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Leukocytes/immunology
MH  - Malaysia
MH  - Population Groups/*genetics
EDAT- 2009/12/17 06:00
MHDA- 2010/06/19 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - TAN1417 [pii]
AID - 10.1111/j.1399-0039.2009.01417.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Feb;75(2):151-8. doi: 10.1111/j.1399-0039.2009.01417.x. 
      Epub 2009 Dec 14.