PMID- 20003377
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20240317
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 9
DP  - 2009 Dec 12
TI  - Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in 
      Chongqing, China.
PG  - 201
LID - 10.1186/1471-2334-9-201 [doi]
AB  - BACKGROUND: The human immunodeficiency virus type 1(HIV-1) epidemic in Chongqing, 
      China, is increasing rapidly with the dominant subtype of CRF07_BC over the past 
      3 years. Since human leukocyte antigen (HLA) polymorphisms have shown strong 
      association with susceptibility/resistance to HIV-1 infection from individuals 
      with different ethnic backgrounds, a recent investigation on frequencies of HLA 
      class I and class II alleles in a Chinese cohort also indicated that similar 
      correlation existed in HIV infected individuals from several provinces in China, 
      however, such information is unavailable in Chongqing, southwest China. METHODS: 
      In this population-based study, we performed polymerase chain reaction analysis 
      with sequence-specific oligonucleotide probes (PCR-SSOP) for 
      intermediate-low-resolution HLA typing in a cohort of 549 HIV-1 infected 
      individuals, another 2475 healthy subjects from the Han nationality in Chongqing, 
      China, were selected as population control. We compared frequencies of HLA-A, B, 
      DRB1 alleles, haplotypes and genotypes between the two groups, and analyzed their 
      association with HIV-1 susceptibility or resistance. RESULTS: The genetic profile 
      of HLA (A, B, DRB1) alleles of HIV-1 infected individuals from Chongqing Han of 
      China was obtained. Several alleles of HLA-B such as B*46 (P = 0.001, OR = 1.38, 
      95%CI = 1.13-1.68), B*1501G(B62) (P = 0.013, OR = 1.42, 95%CI = 1.08-1.88), B*67 
      (P = 0.022, OR = 2.76, 95%CI = 1.16-6.57), B*37 (P = 0.014, OR = 1.93, 95%CI = 
      1.14-3.28) and B*52 (P = 0.038, OR = 1.64, 95%CI = 1.03-2.61) were observed to 
      have association with susceptibility to HIV-1 infection in this population. In 
      addition, the haplotype analysis revealed that A*11-B*46, A*24-B*54 and A*01-B*37 
      for 2-locus, and A*11-B*46-DRB1*09, A*02-B*46-DRB1*08, A*11-B*4001G-DRB1*15, 
      A*02-B*4001G-DRB1*04, A*11-B*46-DRB1*08 and A*02-B*4001G-DRB1*12 for 3-locus had 
      significantly overrepresented in HIV-1 infected individuals, whereas 
      A*11-B*1502G, A*11-B*1502G-DRB1*12 and A*33-B*58-DRB1*13 were underrepresented. 
      However, the low-resolution homozygosity of HLA-A, B, DRB1 loci and HLA-Bw4/Bw6 
      genotypes did not differ significantly between the two groups. CONCLUSION: These 
      results may contribute to the database of HLA profiles in HIV-1 infected Chinese 
      population, consequently, the association of certain HLA alleles with 
      susceptibility or resistance to HIV-1 infection would provide with clues in 
      choosing proper preventive strategies against HIV-1 infection and developing 
      effective HIV-1 vaccines in Chinese population, especially for those in southwest 
      China.
FAU - Huang, Xia
AU  - Huang X
AD  - Department of Epidemiology, Third Military Medical University, Chongqing, PR 
      China.
FAU - Ling, Hua
AU  - Ling H
FAU - Mao, Wei
AU  - Mao W
FAU - Ding, Xianbin
AU  - Ding X
FAU - Zhou, Quanhua
AU  - Zhou Q
FAU - Han, Mei
AU  - Han M
FAU - Wang, Fang
AU  - Wang F
FAU - Cheng, Lei
AU  - Cheng L
FAU - Xiong, Hongyan
AU  - Xiong H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091212
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genetics, Population
MH  - HIV Infections/*genetics/immunology
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Young Adult
PMC - PMC2797796
EDAT- 2009/12/17 06:00
MHDA- 2010/02/19 06:00
PMCR- 2009/12/12
CRDT- 2009/12/17 06:00
PHST- 2008/12/29 00:00 [received]
PHST- 2009/12/12 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
PHST- 2009/12/12 00:00 [pmc-release]
AID - 1471-2334-9-201 [pii]
AID - 10.1186/1471-2334-9-201 [doi]
PST - epublish
SO  - BMC Infect Dis. 2009 Dec 12;9:201. doi: 10.1186/1471-2334-9-201.