PMID- 20004019
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20220316
IS  - 1878-1667 (Electronic)
IS  - 0147-9571 (Linking)
VI  - 33
IP  - 6
DP  - 2010 Dec
TI  - Acute phase response in porcine reproductive and respiratory syndrome virus 
      infection.
PG  - e51-8
LID - 10.1016/j.cimid.2009.11.003 [doi]
AB  - This study was focused on the changes observed in the serum concentration of 
      haptoglobin (Hp), C-reactive protein (CRP), serum amyloid A (SAA) and Pig-major 
      acute protein (Pig-MAP), during experimental porcine reproductive and respiratory 
      syndrome virus (PRRSV) infection and in their relationship with the expression of 
      interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha 
      (TNF-alpha). Hp and Pig-MAP serum levels were increased at 10 dpi, but CRP and SAA 
      showed a delayed and highly variable increase. All three proinflammatory 
      cytokines were poorly expressed, and only a mild increase in IL-1beta was observed 
      at 7 dpi. The increased expression of Hp coincided with the light enhancement 
      observed in both IL-6 and TNF-alpha, and might be related with an increased 
      expression of IL-10. The low expression of TNF-alpha might point to a possible 
      mechanism of viral evasion of host-immune response. This issue and the delayed 
      expression of CRP and SAA should be taken into account in future studies about 
      modulation of the immune response by PRRSV infection.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Gomez-Laguna, J
AU  - Gomez-Laguna J
AD  - Department of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, 
      Cordoba University, 14014 Cordoba, Spain. v92golaj@uco.es
FAU - Salguero, F J
AU  - Salguero FJ
FAU - Pallares, F J
AU  - Pallares FJ
FAU - Fernandez de Marco, M
AU  - Fernandez de Marco M
FAU - Barranco, I
AU  - Barranco I
FAU - Ceron, J J
AU  - Ceron JJ
FAU - Martinez-Subiela, S
AU  - Martinez-Subiela S
FAU - Van Reeth, K
AU  - Van Reeth K
FAU - Carrasco, L
AU  - Carrasco L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091208
PL  - England
TA  - Comp Immunol Microbiol Infect Dis
JT  - Comparative immunology, microbiology and infectious diseases
JID - 7808924
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Haptoglobins)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (MAP protein, Sus scrofa)
RN  - 0 (Serum Amyloid A Protein)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Proteins/*analysis/genetics/metabolism
MH  - *Acute-Phase Reaction
MH  - Animals
MH  - C-Reactive Protein/analysis/metabolism
MH  - Cytokines/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Haptoglobins/analysis/metabolism
MH  - Immunomodulation
MH  - Interleukin-1beta/blood
MH  - Interleukin-6/blood
MH  - Porcine Reproductive and Respiratory 
      Syndrome/*blood/*immunology/pathology/virology
MH  - Porcine respiratory and reproductive syndrome virus/isolation & 
      purification/physiology
MH  - Serum Amyloid A Protein/analysis/metabolism
MH  - Swine
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Viremia/veterinary
EDAT- 2009/12/17 06:00
MHDA- 2011/05/26 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/07/29 00:00 [received]
PHST- 2009/11/11 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - S0147-9571(09)00064-2 [pii]
AID - 10.1016/j.cimid.2009.11.003 [doi]
PST - ppublish
SO  - Comp Immunol Microbiol Infect Dis. 2010 Dec;33(6):e51-8. doi: 
      10.1016/j.cimid.2009.11.003. Epub 2009 Dec 8.