PMID- 20004110
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20211020
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Mar
TI  - Metabolic reprogramming, caloric restriction and aging.
PG  - 134-41
LID - 10.1016/j.tem.2009.11.005 [doi]
AB  - Caloric restriction (CR) without malnutrition slows the aging process and extends 
      lifespan in diverse species by unknown mechanisms. The inverse linear 
      relationship between calorie intake and lifespan suggests that regulators of 
      energy metabolism are important in the actions of CR. Studies in several species 
      reveal tissue-specific changes in energy metabolism with CR and suggest that 
      metabolic reprogramming plays a critical role in its mechanism of aging 
      retardation. We herein describe common signatures of CR and suggest how they can 
      slow aging. We discuss recent advances in understanding the function of key 
      metabolic regulators that probably coordinate the response to altered nutrient 
      availability with CR and how the pathways they regulate can retard the aging 
      process.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Anderson, Rozalyn M
AU  - Anderson RM
AD  - Geriatric Research, Education and Clinical Center, William S. Middleton Memorial 
      Veterans Hospital, University of Wisconsin-Madison, Madison, WI 53705, USA. 
      rmanderson5@wisc.edu
FAU - Weindruch, Richard
AU  - Weindruch R
LA  - eng
GR  - UL1 RR025011-01/RR/NCRR NIH HHS/United States
GR  - AG11915/AG/NIA NIH HHS/United States
GR  - P20 CA103697-05/CA/NCI NIH HHS/United States
GR  - UL1 RR025011/RR/NCRR NIH HHS/United States
GR  - P20 CA103697/CA/NCI NIH HHS/United States
GR  - UL1RR025011/RR/NCRR NIH HHS/United States
GR  - CA103697/CA/NCI NIH HHS/United States
GR  - P01 AG011915-14/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20091207
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
SB  - IM
MH  - *Aging
MH  - Animals
MH  - *Caloric Restriction
MH  - Energy Metabolism/genetics/physiology
MH  - Humans
MH  - Models, Biological
MH  - Signal Transduction/genetics/physiology
PMC - PMC2831168
MID - NIHMS163781
EDAT- 2009/12/17 06:00
MHDA- 2010/05/27 06:00
PMCR- 2011/03/01
CRDT- 2009/12/17 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2009/11/06 00:00 [revised]
PHST- 2009/11/17 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - S1043-2760(09)00194-5 [pii]
AID - 10.1016/j.tem.2009.11.005 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2010 Mar;21(3):134-41. doi: 10.1016/j.tem.2009.11.005. 
      Epub 2009 Dec 7.