PMID- 20004219
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 208
IP  - 1
DP  - 2010 Mar 17
TI  - The orbitofrontal cortex is not necessary for acquisition or remote recall of 
      socially transmitted food preferences.
PG  - 243-9
LID - 10.1016/j.bbr.2009.12.001 [doi]
AB  - A role for prefrontal cortex has been proposed in systems consolidation of 
      memory. The current study examined the effects of excitotoxic lesions of the 
      orbitofrontal cortex (OFC) in rats on acquisition and remote recall of socially 
      transmitted food preferences (STFP). Subjects received excitotoxic lesions of the 
      OFC, and they were trained on two food preferences. They were tested 1h after the 
      first training session to determine the effect of the lesion on acquisition. The 
      following day, they were trained on a second preference and tested 10 days later 
      to determine the effect of the lesion on remote recall. OFC lesions did not 
      impair either STFP acquisition or remote recall in comparisons with sham-operated 
      animals. In addition, a subset of animals underwent odor discrimination and 
      reversal training. Consistent with previous reports, subjects with OFC lesions 
      required more trials to reach criterion and made more errors during reversal 
      training than did sham-operated animals. Taken together, the results of the 
      present study indicate that the orbitofrontal cortex is not necessary for 
      acquisition or systems consolidation of socially transmitted food preferences.
CI  - Copyright 2009 Elsevier B.V. All rights reserved.
FAU - Smith, Clayton A
AU  - Smith CA
AD  - Neuroscience Program, Tulane University, New Orleans, LA 70118, USA.
FAU - East, Brett S
AU  - East BS
FAU - Colombo, Paul J
AU  - Colombo PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20091211
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Behavior, Animal/physiology
MH  - Discrimination, Psychological/physiology
MH  - Food Preferences/*physiology
MH  - Male
MH  - Mental Recall/*physiology
MH  - Odorants
MH  - Origanum
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reward
MH  - *Social Behavior
EDAT- 2009/12/17 06:00
MHDA- 2010/05/04 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/10/14 00:00 [received]
PHST- 2009/11/21 00:00 [revised]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - S0166-4328(09)00727-X [pii]
AID - 10.1016/j.bbr.2009.12.001 [doi]
PST - ppublish
SO  - Behav Brain Res. 2010 Mar 17;208(1):243-9. doi: 10.1016/j.bbr.2009.12.001. Epub 
      2009 Dec 11.