PMID- 20004859
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20091217
IS  - 1873-5150 (Electronic)
IS  - 0887-8994 (Linking)
VI  - 42
IP  - 1
DP  - 2010 Jan
TI  - Febrile seizures and primary human herpesvirus 6 infection.
PG  - 28-31
LID - 10.1016/j.pediatrneurol.2009.07.016 [doi]
AB  - Primary human herpesvirus 6 infection is acquired mainly during the first two 
      years of life and is often associated with febrile seizures. The aim of the 
      present study was to investigate in Greece the frequency and clinical 
      characteristics of primary human herpesvirus 6 (HHV-6) infection in hospitalized 
      children with febrile seizures. Children aged from 6 months to 5 years without 
      known neurologic disease were examined for primary HHV-6 infection, by real-time 
      polymerase chain reaction in acute-phase plasma and by indirect immunofluorescent 
      assay for antibody titers in acute and convalescent serum. Of 65 children 
      included in the analysis, 55 experienced the first febrile episode of seizures 
      and 10 the second. Primary HHV-6 infection was verified in 10 of 55 children with 
      a first febrile episode (18%), whereas none of the 10 children with a second 
      episode of seizures had primary HHV-6 infection. Eight children were infected 
      with HHV-6 type B and two with type A. None of the 85 control subjects had 
      primary HHV-6 infection, but 49% had immunoglobulin G antibodies against the 
      virus. These findings suggest that primary HHV-6 infection is frequently 
      associated with febrile seizures in children in this geographic region and should 
      be considered, especially for a first episode of febrile seizures.
FAU - Laina, Ioanna
AU  - Laina I
AD  - First Department of Pediatrics, Aghia Sophia Children's Hospital, Athens 
      University, Athens, Greece.
FAU - Syriopoulou, Vassiliki P
AU  - Syriopoulou VP
FAU - Daikos, George L
AU  - Daikos GL
FAU - Roma, Eleftheria S
AU  - Roma ES
FAU - Papageorgiou, Foteini
AU  - Papageorgiou F
FAU - Kakourou, Talia
AU  - Kakourou T
FAU - Theodoridou, Maria
AU  - Theodoridou M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Neurol
JT  - Pediatric neurology
JID - 8508183
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Child, Preschool
MH  - DNA, Viral/blood
MH  - Female
MH  - Fluoroimmunoassay
MH  - Greece
MH  - *Herpesvirus 6, Human/genetics/immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Infant
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/blood/*complications
MH  - Seizures, Febrile/blood/*etiology
EDAT- 2009/12/17 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/03/04 00:00 [received]
PHST- 2009/07/22 00:00 [revised]
PHST- 2009/07/22 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S0887-8994(09)00390-7 [pii]
AID - 10.1016/j.pediatrneurol.2009.07.016 [doi]
PST - ppublish
SO  - Pediatr Neurol. 2010 Jan;42(1):28-31. doi: 10.1016/j.pediatrneurol.2009.07.016.