PMID- 20005362
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20211028
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 41
IP  - 10
DP  - 2009 Dec
TI  - Pilot study: association of traditional and genetic risk factors and new-onset 
      diabetes mellitus following kidney transplantation.
PG  - 4172-7
LID - 10.1016/j.transproceed.2009.08.063 [doi]
AB  - INTRODUCTION: New-onset diabetes mellitus, which occurs after kidney transplant 
      and type 2 diabetes mellitus (T2DM), shares common risk factors and antecedents 
      in impaired insulin secretion and action. Several genetic polymorphisms have been 
      shown to be associated with T2DM. We hypothesized that transplant recipients who 
      carry risk alleles for T2DM are "tipped over" to develop diabetes mellitus in the 
      posttransplant milieu. METHODS: We investigated the association of genetic and 
      traditional risk factors present before transplantation and the development of 
      new-onset diabetes mellitus after kidney transplantation (NODAT). Markers in 8 
      known T2DM-linked genes were genotyped using either the iPLEX assay or allelic 
      discrimination (AD)-PCR in the study cohort testing for association with NODAT. 
      We used univariate and multivariate logistic regression models for the 
      association of pretransplant nongenetic and genetic variables with the 
      development of NODAT. RESULTS: The study cohort included 91 kidney transplant 
      recipients with at least 1 year posttransplant follow-up, including 22 who 
      developed NODAT. We observed that increased age, family history of T2DM, 
      pretransplant obesity, and triglyceridemia were associated with NODAT 
      development. In addition, we observed positive trends, although statistically not 
      significant, for association between T2DM-associated genes and NODAT. 
      CONCLUSIONS: These findings demonstrated an increased NODAT risk among patient 
      with a positive family history for T2DM, which, in conjunction with the observed 
      positive predictive trends of known T2DM-associated genetic polymorphisms with 
      NODAT, was suggestive of a genetic predisposition to NODAT.
FAU - Chakkera, H A
AU  - Chakkera HA
AD  - Division of Transplantation Medicine, Mayo Clinic, 5777 E. Mayo Blvd., Phoenix, 
      AZ 85259, Arizona, USA. chakkera.harini@mayo.edu
FAU - Hanson, R L
AU  - Hanson RL
FAU - Raza, S M
AU  - Raza SM
FAU - DiStefano, J K
AU  - DiStefano JK
FAU - Millis, M P
AU  - Millis MP
FAU - Heilman, R L
AU  - Heilman RL
FAU - Mulligan, D C
AU  - Mulligan DC
FAU - Reddy, K S
AU  - Reddy KS
FAU - Mazur, M J
AU  - Mazur MJ
FAU - Hamawi, K
AU  - Hamawi K
FAU - Moss, A A
AU  - Moss AA
FAU - Mekeel, K L
AU  - Mekeel KL
FAU - Cerhan, J R
AU  - Cerhan JR
LA  - eng
GR  - Z01 DK069096-01/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Age Factors
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Diabetes Mellitus/*epidemiology/*genetics
MH  - Family
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Medical History Taking
MH  - Pilot Projects
MH  - *Polymorphism, Single Nucleotide
MH  - Postoperative Complications/*epidemiology
MH  - Regression Analysis
MH  - Risk Factors
MH  - Weight Gain/*genetics
PMC - PMC3478878
MID - NIHMS410854
EDAT- 2009/12/17 06:00
MHDA- 2010/04/24 06:00
PMCR- 2012/10/23
CRDT- 2009/12/17 06:00
PHST- 2009/04/15 00:00 [received]
PHST- 2009/06/28 00:00 [revised]
PHST- 2009/08/17 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
PHST- 2012/10/23 00:00 [pmc-release]
AID - S0041-1345(09)01341-4 [pii]
AID - 10.1016/j.transproceed.2009.08.063 [doi]
PST - ppublish
SO  - Transplant Proc. 2009 Dec;41(10):4172-7. doi: 10.1016/j.transproceed.2009.08.063.