PMID- 20005542
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20100524
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 59
IP  - 6
DP  - 2010 Jun
TI  - Fasting cholesteryl ester transfer protein concentration is independently 
      associated with the postprandial decrease in high-density lipoprotein cholesterol 
      concentration after fat-rich meals: the Hoorn prandial study.
PG  - 854-60
LID - 10.1016/j.metabol.2009.10.002 [doi]
AB  - The aim of the study was to test whether fasting or postprandial cholesteryl 
      ester transfer protein (CETP) concentrations are associated with postprandial 
      changes in high-density lipoprotein cholesterol (HDL-c) concentrations after 
      fat-rich or carbohydrate-rich meals. Postmenopausal women (76 with normal glucose 
      metabolism [NGM], 41 with type 2 diabetes mellitus [T2DM], and 38 T2DM women with 
      statin therapy [T2DM-ST]) received 2 consecutive fat-rich or carbohydrate-rich 
      meals on separate occasions. Linear regression analysis was performed to assess 
      the associations of fasting CETP and postprandial changes of CETP with 
      postprandial changes in HDL-c. Mean plasma HDL-c concentrations decreased 
      significantly after the fat-rich meals: 0.18 +/- 0.09 mmol/L in NGM, 0.16 +/- 
      0.09 mmol/L in T2DM, and 0.14 +/- 0.08 mmol/L in T2DM-ST women. This effect was 
      smaller after using carbohydrate-rich meals: 0.12 +/- 0.09 mmol/L in the NGM, 
      0.12 +/- 0.08 mmol/L in the T2DM, and 0.10 +/- 0.05 mmol/L in the T2DM-ST study 
      group. Higher fasting but not postprandial CETP concentrations were associated 
      with a larger postprandial decrease in HDL-c (beta -0.034; 95% confidence 
      interval, -0.067 to -0.001) after the fat-rich meals. This association was 
      independent of the postprandial increase in triglycerides and similar among the 3 
      study groups. A high fasting CETP concentration may contribute to the 
      postprandial atherogenic lipoprotein profile in postmenopausal women by 
      decreasing HDL-c after fat-rich meals. This effect is independent from the 
      postprandial increase in triglycerides.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Alssema, Marjan
AU  - Alssema M
AD  - EMGO Institute for Health and Care Research, VU University Medical Center, 
      Amsterdam, The Netherlands. m.alssema@vumc.nl
FAU - El-Harchaoui, Karim
AU  - El-Harchaoui K
FAU - Schindhelm, Roger K
AU  - Schindhelm RK
FAU - Diamant, Michaela
AU  - Diamant M
FAU - Nijpels, Giel
AU  - Nijpels G
FAU - Kostense, Piet J
AU  - Kostense PJ
FAU - Teerlink, Tom
AU  - Teerlink T
FAU - Heine, Robert J
AU  - Heine RJ
FAU - Dallinga-Thie, Geesje M
AU  - Dallinga-Thie GM
FAU - Kuivenhoven, Jan A
AU  - Kuivenhoven JA
FAU - Dekker, Jacqueline M
AU  - Dekker JM
FAU - Scheffer, Peter G
AU  - Scheffer PG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091216
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - Cholesterol Ester Transfer Proteins/*blood
MH  - Cholesterol, HDL/*blood
MH  - Diabetes Mellitus, Type 2/blood
MH  - Dietary Carbohydrates/pharmacology
MH  - Dietary Fats/*pharmacology
MH  - Fasting/blood
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
MH  - Hypercholesterolemia/blood/drug therapy
MH  - Linear Models
MH  - Middle Aged
MH  - Postmenopause/metabolism
MH  - Postprandial Period/*physiology
MH  - Triglycerides/blood
EDAT- 2009/12/17 06:00
MHDA- 2010/06/12 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/07/07 00:00 [received]
PHST- 2009/09/24 00:00 [revised]
PHST- 2009/10/02 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - S0026-0495(09)00425-9 [pii]
AID - 10.1016/j.metabol.2009.10.002 [doi]
PST - ppublish
SO  - Metabolism. 2010 Jun;59(6):854-60. doi: 10.1016/j.metabol.2009.10.002. Epub 2009 
      Dec 16.