PMID- 20005972
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20101118
IS  - 1878-5875 (Electronic)
IS  - 1357-2725 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Mar
TI  - SRY: A transcriptional activator of mammalian testis determination.
PG  - 417-20
LID - 10.1016/j.biocel.2009.12.005 [doi]
AB  - Sry (sex-determining region Y) is the sex-determining gene on the mammalian Y 
      chromosome, which encodes a transcription factor containing a DNA-binding domain 
      characteristic of some high mobility group proteins (HMG box). It is the founder 
      member of the Sox (Sry-related HMG box) gene family and is therefore classified 
      in the Sox A group. In mice, the transient expression of Sry between 10.5 and 
      12.5 dpc triggers the differentiation of Sertoli cells from the supporting cell 
      precursor lineage, which would otherwise give rise to granulosa cells in ovaries. 
      However, little was known about the target genes of SRY and molecular mechanisms 
      how SRY leads to testis development. Recent work has provided evidence that SRY 
      binds directly to a testis-specific enhancer of Sox9 (TES) and activates Sox9 
      expression in co-operation with steroidogenic factor 1 (SF1). Furthermore, this 
      SRY action is limited to a certain time period during embryogenesis.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Sekido, Ryohei
AU  - Sekido R
AD  - Division of Developmental Genetics, MRC National Institute for Medical Research, 
      The Ridgeway, Mill Hill, London NW7 AA, UK. rsekido@nimr.mrc.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091218
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (Sex-Determining Region Y Protein)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Animals
MH  - Male
MH  - Mammals/*genetics
MH  - Models, Genetic
MH  - *Sex Determination Processes
MH  - Sex-Determining Region Y Protein/chemistry/genetics/*metabolism
MH  - Testis/*embryology
MH  - Trans-Activators/chemistry/genetics/*metabolism
RF  - 40
EDAT- 2009/12/17 06:00
MHDA- 2010/05/06 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/10/27 00:00 [received]
PHST- 2009/12/03 00:00 [revised]
PHST- 2009/12/07 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - S1357-2725(09)00358-6 [pii]
AID - 10.1016/j.biocel.2009.12.005 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2010 Mar;42(3):417-20. doi: 
      10.1016/j.biocel.2009.12.005. Epub 2009 Dec 18.