PMID- 20006203
OWN - NLM
STAT- MEDLINE
DCOM- 20100108
LR  - 20151119
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jan
TI  - S-100beta and neuron-specific enolase levels in carbon monoxide-related brain 
      injury.
PG  - 61-7
LID - 10.1016/j.ajem.2008.10.032 [doi]
AB  - INTRODUCTION: Carbon monoxide (CO) toxicity may cause persistent injuries in 
      tissues sensitive to hypoxia. Neuropsychiatric sequelae may be observed in about 
      67% of cases after severe CO exposure. AIM: The aims of this study were to 
      demonstrate the usefulness of S-100beta and neuron-specific enolase (NSE) in CO 
      intoxications, show the degree of neurological response, and determine the 
      indications for hyperbaric oxygen treatment (HBOT) as biochemical markers. 
      RESULTS: The S-100beta and NSE levels of the sera of 30 patients were studied 
      upon admittance and at the third and sixth hours. S-100beta levels were found to 
      be high in all 3 analyses. There was no significant change in NSE levels. When 
      the S-100beta levels were compared with Glasgow Coma Scale levels, a strong 
      negative correlation was found for all hours (r = -0.7, -0.8; P = .00). The 
      correlation between S-100beta and carboxyhemoglobin levels at the initial hour 
      was found to be statistically significant (r = 0.4; P = .01). The S-100beta 
      levels in patients receiving HBOT showed a considerable decrease compared with 
      those in patients not receiving the treatment. The same decrease was valid for 
      NSE, although it was insignificant. CONCLUSION: S-100beta may be useful in 
      evaluating intoxications as an early biochemical marker in CO intoxications, as 
      well as in the differential diagnosis due to other causes, and in determining 
      HBOT indications.
FAU - Cakir, Zeynep
AU  - Cakir Z
AD  - Department of Emergency Medicine, Ataturk University, Medical School, 25090 
      Erzurum, Turkey.
FAU - Aslan, Sahin
AU  - Aslan S
FAU - Umudum, Zuhal
AU  - Umudum Z
FAU - Acemoglu, Hamit
AU  - Acemoglu H
FAU - Akoz, Ayhan
AU  - Akoz A
FAU - Turkyilmaz, Sule
AU  - Turkyilmaz S
FAU - Ozturk, Nurinnisa
AU  - Ozturk N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - 0 (Biomarkers)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain Diseases/*blood/etiology
MH  - Carbon Monoxide Poisoning/*blood/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Growth Factors/*blood
MH  - Phosphopyruvate Hydratase/*blood
MH  - S100 Calcium Binding Protein beta Subunit
MH  - S100 Proteins/*blood
MH  - Time Factors
EDAT- 2009/12/17 06:00
MHDA- 2010/01/09 06:00
CRDT- 2009/12/17 06:00
PHST- 2008/08/23 00:00 [received]
PHST- 2008/10/24 00:00 [revised]
PHST- 2008/10/26 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/01/09 06:00 [medline]
AID - S0735-6757(08)00781-X [pii]
AID - 10.1016/j.ajem.2008.10.032 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2010 Jan;28(1):61-7. doi: 10.1016/j.ajem.2008.10.032.