PMID- 20006664
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20190402
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 31
IP  - 2
DP  - 2010 Feb
TI  - Expression of human beta-defensin-2 in intratumoral vascular endothelium and in 
      endothelial cells induced by transforming growth factor beta.
PG  - 195-201
LID - 10.1016/j.peptides.2009.12.008 [doi]
AB  - Human beta-defensin-2 (hBD-2) is a small cationic peptide originally identified 
      from psoriatic skin lesions as an antimicrobial agent of the innate immune 
      system. The expression of hBD-2 is believed to be induced exclusively in 
      epithelial cells by microbial components and certain proinflammatory cytokines, 
      such as interleukin-1 beta (IL-1 beta). In this study, we report, for the first 
      time, that hBD-2 is expressed in vascular endothelial cells associated with oral 
      squamous cell carcinoma (OSCC) and Kaposi's sarcoma lesions, but not in that of 
      normal stroma. Expression of hBD-2 in vascular endothelial cells was further 
      substantiated by in vitro experiments using cultured human umbilical vein 
      endothelial cells (HUVECs). Transforming growth factor beta1 (TGF beta 1) and 
      IL-1 beta, two well-known tumorigenic inflammatory mediators, induce hBD-2 
      transcript and peptide expression in HUVECs. However, TGF beta 1 does not 
      stimulate hBD-2 expression in oral epithelial cells. In addition, proinflammatory 
      cytokines and microbial reagents do not induce the expression of hBD-1 and hBD-3 
      in HUVECs. Since hBD-2 has been shown to modulate migration, proliferation, and 
      tube formation of HUVECs in vitro and participate in immune cell trafficking, its 
      expression in vascular endothelial cells located within malignant lesions may 
      play a role in tumor angiogenesis and cancer metastasis.
CI  - (c) 2009 Elsevier Inc. All rights reserved.
FAU - Kawsar, Hameem I
AU  - Kawsar HI
AD  - Department of Biological Sciences, Case Western Reserve University School of 
      Dental Medicine, 10900 Euclid Ave., Cleveland, OH 44106, USA.
FAU - Ghosh, Santosh K
AU  - Ghosh SK
FAU - Hirsch, Stanley A
AU  - Hirsch SA
FAU - Koon, Henry B
AU  - Koon HB
FAU - Weinberg, Aaron
AU  - Weinberg A
FAU - Jin, Ge
AU  - Jin G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091216
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (DEFB103A protein, human)
RN  - 0 (DEFB4A protein, human)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (beta-Defensins)
SB  - IM
MH  - Carcinoma, Squamous Cell/metabolism
MH  - Cytoplasm/metabolism
MH  - Endothelial Cells/drug effects/*metabolism
MH  - Endothelium, Vascular/*metabolism
MH  - Gene Expression/drug effects/genetics
MH  - Humans
MH  - Interleukin-1beta/pharmacology
MH  - Mouth Neoplasms/metabolism
MH  - Neoplasms/blood supply/*metabolism
MH  - Sarcoma, Kaposi/metabolism
MH  - Transforming Growth Factor beta/*pharmacology
MH  - beta-Defensins/genetics/*metabolism
EDAT- 2009/12/17 06:00
MHDA- 2010/04/30 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2009/12/03 00:00 [revised]
PHST- 2009/12/04 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - S0196-9781(09)00528-2 [pii]
AID - 10.1016/j.peptides.2009.12.008 [doi]
PST - ppublish
SO  - Peptides. 2010 Feb;31(2):195-201. doi: 10.1016/j.peptides.2009.12.008. Epub 2009 
      Dec 16.