PMID- 20006817
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20220310
IS  - 1528-3933 (Electronic)
IS  - 1091-8531 (Print)
IS  - 1091-8531 (Linking)
VI  - 13
IP  - 6
DP  - 2009 Dec
TI  - Spectral domain optical coherence tomography for detection of foveal morphology 
      in patients with nystagmus.
PG  - 563-6
LID - 10.1016/j.jaapos.2009.09.019 [doi]
AB  - PURPOSE: To evaluate the feasibility of spectral domain optical coherence 
      tomography (SD-OCT) macular scanning as a means of studying the afferent visual 
      system in nystagmus patients. METHODS: Nystagmus patients who underwent SD-OCT, 
      clinical evaluation, and eye movement recordings were recruited for this 
      prospective, single-center, noncomparative study. Three SD-OCT macular 
      three-dimensional cube scans per eye (200 x 200 x 1024 samplings in a 6 x 6 mm 
      region) were obtained for qualitative retinal morphology analysis. RESULTS: 
      Nineteen patients (6-68 years; average, 19 years) were analyzed. Of these, 17 
      patients had infantile nystagmus syndrome, and 2 had fusion maldevelopment 
      nystagmus; 17 patients (89%) had associated sensory system abnormalities, 
      including 9 (47%) with albinism. Macular images were successfully obtained in all 
      but 1 patient (95%). Of the 8 successfully imaged oculocutaneous patients, 7 
      patients demonstrated "fovea plana," and all demonstrated abnormal morphology. 
      CONCLUSION: SD-OCT reliably provides detailed structural imaging of the fovea in 
      nystagmus patients.
FAU - Cronin, Tara H
AU  - Cronin TH
AD  - The UPMC and Children's Hospital Of Pittsburgh Eye Centers and The Laboratory of 
      Visual and Ocular Motor Physiology Pittsburgh, PA 15201, USA.
FAU - Hertle, Richard W
AU  - Hertle RW
FAU - Ishikawa, Hiroshi
AU  - Ishikawa H
FAU - Schuman, Joel S
AU  - Schuman JS
LA  - eng
GR  - R01 EY013178/EY/NEI NIH HHS/United States
GR  - R01 EY013178-09/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J AAPOS
JT  - Journal of AAPOS : the official publication of the American Association for 
      Pediatric Ophthalmology and Strabismus
JID - 9710011
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Eye Movements
MH  - Feasibility Studies
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Middle Aged
MH  - Nystagmus, Pathologic/*diagnosis
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
PMC - PMC2917909
MID - NIHMS220450
EDAT- 2009/12/17 06:00
MHDA- 2010/03/13 06:00
PMCR- 2010/12/01
CRDT- 2009/12/17 06:00
PHST- 2009/04/18 00:00 [received]
PHST- 2009/09/16 00:00 [revised]
PHST- 2009/09/17 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - S1091-8531(09)00360-7 [pii]
AID - 10.1016/j.jaapos.2009.09.019 [doi]
PST - ppublish
SO  - J AAPOS. 2009 Dec;13(6):563-6. doi: 10.1016/j.jaapos.2009.09.019.