PMID- 20006905
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20211020
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 117
IP  - 2
DP  - 2010 Feb
TI  - Hypopyon in patients with uveitis.
PG  - 366-72
LID - 10.1016/j.ophtha.2009.07.025 [doi]
AB  - PURPOSE: To evaluate the risk of and risk factors for hypopyon among patients 
      with uveitis and to evaluate the risk of visual changes and complications after 
      hypopyon. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients with uveitis 
      at 4 academic ocular inflammation subspecialty practices. METHODS: Data were 
      ascertained by standardized chart review. MAIN OUTCOME MEASURES: Prevalence and 
      incidence of hypopyon, risk factors for hypopyon, and incidence of visual acuity 
      changes and ocular complications after hypopyon. RESULTS: Among 4911 patients 
      with uveitis, 41 (8.3/1000) cases of hypopyon were identified at the time of 
      cohort entry. Of these, 2885 initially free of hypopyon were followed over 9451 
      person-years, during which 81 patients (2.8%) developed hypopyon (8.57/1000 
      person-years). Risk factors for incident hypopyon included Behcet's disease 
      (adjusted relative risk [RR]=5.30; 95% confidence interval [CI], 2.76-10.2), 
      spondyloarthropathy (adjusted RR=2.86; 95% CI, 1.48-5.52), and human leukocyte 
      antigen (HLA)-B27 positivity (adjusted RR=2.04; 95% CI, 1.17-3.56). Patients with 
      both a spondyloarthropathy and HLA-B27 had a higher risk than either factor alone 
      (crude RR=4.39; 95% CI, 2.26-8.51). Diagnosis of intermediate uveitis (+/- 
      anterior uveitis) was associated with a lower risk of hypopyon (with respect to 
      anterior uveitis only, adjusted RR=0.35; 95% CI, 0.15-0.85). Hypopyon incidence 
      tended to be lower among patients with sarcoidosis (crude RR=0.22; 95% CI, 
      0.06-0.90; adjusted RR=-0.28; 95% CI, 0.07-1.15). Post-hypopyon eyes and eyes not 
      developing hypopyon had a similar incidence of band keratopathy, posterior 
      synechiae, ocular hypertension, hypotony, macular edema, epiretinal membrane, 
      cataract surgery, or glaucoma surgery. Post-hypopyon eyes were more likely than 
      eyes not developing hypopyon to gain 3 lines of vision (crude RR=1.54; 95% CI, 
      1.05-2.24) and were less likely to develop 20/200 or worse visual acuity (crude 
      RR=0.41; 95% CI, 0.17-0.99); otherwise, visual outcomes were similar in these 
      groups. CONCLUSIONS: Hypopyon is an uncommon occurrence in patients with uveitis. 
      Risk factors included Behcet's disease, HLA-B27 positivity, and 
      spondyloarthropathy. Intermediate uveitis cases (+/- anterior uveitis) had a 
      lower risk of hypopyon. On average, post-hypopyon eyes were no more likely than 
      other eyes with uveitis to develop structural ocular complications or lose visual 
      acuity.
CI  - Copyright (c) 2010 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Zaidi, Ali A
AU  - Zaidi AA
AD  - Department of Ophthalmology, The University of Pennsylvania, The Ocular 
      Inflammation Service and Center for Preventive Ophthalmology and Biostatistics, 
      Philadelphia, Pennsylvania, USA.
FAU - Ying, Gui-Shuang
AU  - Ying GS
FAU - Daniel, Ebenezer
AU  - Daniel E
FAU - Gangaputra, Sapna
AU  - Gangaputra S
FAU - Rosenbaum, James T
AU  - Rosenbaum JT
FAU - Suhler, Eric B
AU  - Suhler EB
FAU - Thorne, Jennifer E
AU  - Thorne JE
FAU - Foster, C Stephen
AU  - Foster CS
FAU - Jabs, Douglas A
AU  - Jabs DA
FAU - Levy-Clarke, Grace A
AU  - Levy-Clarke GA
FAU - Nussenblatt, Robert B
AU  - Nussenblatt RB
FAU - Kempen, John H
AU  - Kempen JH
CN  - Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study
LA  - eng
GR  - R01 EY014943/EY/NEI NIH HHS/United States
GR  - R01 EY014943-05/EY/NEI NIH HHS/United States
GR  - R56 EY014943/EY/NEI NIH HHS/United States
GR  - EY014943/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20091214
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anterior Chamber/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Suppuration/diagnosis/*etiology
MH  - Uveitis/*complications
MH  - Vision Disorders/etiology
MH  - Visual Acuity/physiology
MH  - Young Adult
PMC - PMC2819583
MID - NIHMS135108
EDAT- 2009/12/17 06:00
MHDA- 2010/02/25 06:00
PMCR- 2011/02/01
CRDT- 2009/12/17 06:00
PHST- 2009/04/09 00:00 [received]
PHST- 2009/07/13 00:00 [revised]
PHST- 2009/07/20 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - S0161-6420(09)00792-1 [pii]
AID - 10.1016/j.ophtha.2009.07.025 [doi]
PST - ppublish
SO  - Ophthalmology. 2010 Feb;117(2):366-72. doi: 10.1016/j.ophtha.2009.07.025. Epub 
      2009 Dec 14.