PMID- 20007364
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20211020
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 17
IP  - 2
DP  - 2010 Feb
TI  - Association of reduced tumor necrosis factor alpha, gamma interferon, and 
      interleukin-1beta (IL-1beta) but increased IL-10 expression with improved chest 
      radiography in patients with pulmonary tuberculosis.
PG  - 223-31
LID - 10.1128/CVI.00381-09 [doi]
AB  - Mycobacterium tuberculosis infection is a major world health issue. The early 
      identification of patients at risk for a poor response to anti-M. tuberculosis 
      therapy would help elucidate the key players in the anti-M. tuberculosis 
      response. The objective of the present study was to correlate the modulation of 
      cytokine expression (interleukin-1 [IL-1], IL-6, IL-8, IL-10, IL-12, gamma 
      interferon [IFN-gamma], interferon-inducible protein [IP-10], and monocyte 
      chemotactic protein 1 [MCP-1]) with the clinical response to 2 months of 
      intensive therapy. From January to December 2007, 40 M. tuberculosis-infected 
      patients and 40 healthy patients were recruited. After exclusion for diabetes, 32 
      patients and 36 controls were analyzed. The clinical responses of the M. 
      tuberculosis-infected patients on the basis of the findings of chest radiography 
      were compared to their plasma cytokine levels measured before and after 2 months 
      of intensive anti-M. tuberculosis therapy and 6 months of therapy with human 
      cytokine antibody arrays. Chest radiographs of 20 of 32 M. tuberculosis-infected 
      patients showed improvement after 2 months of intensive therapy (early 
      responders), while the M. tuberculosis infections in 12 of 32 of the patients 
      resolved after a further 4 months (late responders). The levels of expression of 
      TNF-alpha, MCP-1, IFN-gamma, and IL-1beta were decreased; and the level of IL-10 
      increased in early responders. After adjustment for age, gender, and the result 
      of sputum culture for M. tuberculosis, significant differences in the levels of 
      MCP-1 and IP-10 expression were observed between the early and the late 
      responders after 2 months of intensive anti-M. tuberculosis therapy. Due to the 
      interpatient variability in IP-10 levels, intrapatient monitoring of IP-10 levels 
      may provide more insight into the M. tuberculosis responder status than 
      comparison between patients. Plasma MCP-1 levels were normalized in patients who 
      had resolved their M. tuberculosis infections. Further studies to evaluate the 
      association of the modulation in MCP-1 levels with early and late responses are 
      warranted.
FAU - Su, Wen-Lin
AU  - Su WL
AD  - Graduate Institute of Medical Sciences, National Defense Medical Center, No.161, 
      Sec. 6, Mincyuan E. Rd., Neihu District, Taipei City 114, Taiwan, Republic of 
      China.
FAU - Perng, Wann-Cherng
AU  - Perng WC
FAU - Huang, Ching-Hui
AU  - Huang CH
FAU - Yang, Cheng-Yu
AU  - Yang CY
FAU - Wu, Chin-Pyng
AU  - Wu CP
FAU - Chen, Jenn-Han
AU  - Chen JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091209
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Antitubercular Agents)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antitubercular Agents/*therapeutic use
MH  - Cytokines/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung/diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/*immunology
MH  - Radiography, Thoracic
MH  - Tuberculosis, Pulmonary/drug therapy/*immunology/*pathology
PMC - PMC2815523
EDAT- 2009/12/17 06:00
MHDA- 2010/03/30 06:00
PMCR- 2010/08/01
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
PHST- 2010/08/01 00:00 [pmc-release]
AID - CVI.00381-09 [pii]
AID - 0381-09 [pii]
AID - 10.1128/CVI.00381-09 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2010 Feb;17(2):223-31. doi: 10.1128/CVI.00381-09. Epub 2009 
      Dec 9.