PMID- 20009418
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20190513
IS  - 1348-9585 (Electronic)
IS  - 1341-9145 (Linking)
VI  - 52
IP  - 1
DP  - 2010
TI  - Matrix metalloproteinase-3 and vitamin d receptor genetic polymorphisms, and 
      their interactions with occupational exposure in lumbar disc degeneration.
PG  - 23-30
AB  - OBJECTIVES: To investigate the occupational and genetic risk factors inducing 
      lumbar disc degeneration in a Chinese population, and to explore their 
      synergistic interactions. METHODS: A case-control study involving 178 low back 
      pain patients with lumbar disc degeneration and 284 controls was carried out. 
      Five types of work-related factors were investigated using questionnaires. 
      Polymerase chain reaction and restriction fragments length polymorphism was used 
      to detect the polymorphisms of MMP-3 (matrix metalloproteinase-3)(rs731236), 
      VDR-Taq (vitamin D receptor-Taq) and VDR-Apa (vitamin D 
      receptor-Apa)(rs35068180). Rothman's synergy index was used to measure the 
      synergistic interactions between gene polymorphisms and occupational risk 
      factors. RESULTS: Family history of lumbar disc diseases, back injury history, 
      whole-body vibration, bending/twisting, heavy physical workload, age, mutation 
      alleles 5A of MMP-3 and A of VDR-Apa were significantly associated with lumbar 
      disc degeneration (OR=12.70, 11.79, 8.96, 5.46, 1.05, 1.96 and 1.70, 
      respectively, p<0.05). Synergistic interactions existed between the mutation 
      allele 5A of MMP-3 and whole-body vibration exposure, the mutation allele 5A of 
      MMP-3 and bending/twisting, and the mutation allele A of VDR-Apa and 
      bending/twisting (SI=13.27, 2.91, 2.35, respectively, p<0.05). CONCLUSIONS: The 
      results of this study suggest that gene-occupation interaction might play a 
      certain role in exaggerating lumbar disc degeneration. There is a possibility 
      that subjects who carry mutation alleles 5A of MMP-3 and/or A of VDR-Apa are more 
      vulnerable to lumbar disc degeneration when they are exposed to whole-body 
      vibration and/or bending/twisting under ergonomic loads.
FAU - Yuan, Han-Yan
AU  - Yuan HY
AD  - Department of Occupational Health, School of Public Health, Fudan University, 
      Shanghai, China.
FAU - Tang, Ying
AU  - Tang Y
FAU - Liang, You-Xin
AU  - Liang YX
FAU - Lei, Ling
AU  - Lei L
FAU - Xiao, Guo-Bing
AU  - Xiao GB
FAU - Wang, Sheng
AU  - Wang S
FAU - Xia, Zhao-Lin
AU  - Xia ZL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091216
PL  - Australia
TA  - J Occup Health
JT  - Journal of occupational health
JID - 9616320
RN  - 0 (Receptors, Calcitriol)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Base Sequence
MH  - China/epidemiology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Intervertebral Disc Displacement/epidemiology/*genetics
MH  - Lumbar Vertebrae/*injuries
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - *Occupational Exposure
MH  - *Polymorphism, Genetic
MH  - Receptors, Calcitriol/*genetics
MH  - Spinal Diseases/genetics
MH  - Surveys and Questionnaires
EDAT- 2009/12/17 06:00
MHDA- 2010/05/11 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - JST.JSTAGE/joh/L8149 [pii]
AID - 10.1539/joh.l8149 [doi]
PST - ppublish
SO  - J Occup Health. 2010;52(1):23-30. doi: 10.1539/joh.l8149. Epub 2009 Dec 16.