PMID- 20010321
OWN - NLM
STAT- MEDLINE
DCOM- 20100303
LR  - 20211020
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Print)
IS  - 0275-004X (Linking)
VI  - 30
IP  - 1
DP  - 2010 Jan
TI  - Retinal pigment epithelial changes in chronic Vogt-Koyanagi-Harada disease: 
      fundus autofluorescence and spectral domain-optical coherence tomography 
      findings.
PG  - 33-41
LID - 10.1097/IAE.0b013e3181c5970d [doi]
AB  - PURPOSE: The purpose of this study was to determine whether fundus 
      autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT) 
      imaging allow better assessment of retinal pigment epithelium and the outer 
      retina in subjects with chronic Vogt-Koyanagi-Harada disease compared with 
      examination and angiography alone. METHODS: A cross-sectional analysis of a 
      series of seven consecutive patients with chronic Vogt-Koyanagi-Harada disease 
      undergoing FAF and SD-OCT was conducted. Chronic disease was defined as duration 
      of intraocular inflammation >3 months. Color fundus photographs were correlated 
      to FAF and SD-OCT images. The images were later correlated to fluorescein 
      angiography and indocyanine green angiography. RESULTS: All patients had sunset 
      glow fundus, which resulted in no apparent corresponding abnormality on FAF or 
      SD-OCT. Lesions with decreased autofluorescence signal were observed in 11 eyes 
      (85%), being associated with loss of the retinal pigment epithelium and 
      involvement of the outer retina on SD-OCT. In 5 eyes (38%), some of these lesions 
      were very subtle on clinical examination but easily detected by FAF. Lesions with 
      increased autofluorescence signal were seen in 8 eyes (61.5%), showing variable 
      involvement of the outer retina on SD-OCT and corresponding clinically to areas 
      of retinal pigment epithelium proliferation and cystoid macular edema. 
      CONCLUSION: Combined use of FAF and SD-OCT imaging allowed noninvasive 
      delineation of retinal pigment epithelium/outer retina changes in patients with 
      chronic Vogt-Koyanagi-Harada disease, which were consistent with previous 
      histopathologic reports. Some of these changes were not apparent on clinical 
      examination.
FAU - Vasconcelos-Santos, Daniel V
AU  - Vasconcelos-Santos DV
AD  - Department of Ophthalmology, University of Southern California, Los Angeles, CA, 
      USA.
FAU - Sohn, Elliott H
AU  - Sohn EH
FAU - Sadda, Srinivas
AU  - Sadda S
FAU - Rao, Narsing A
AU  - Rao NA
LA  - eng
GR  - P30 EY003040/EY/NEI NIH HHS/United States
GR  - P30 EY003040-29/EY/NEI NIH HHS/United States
GR  - EY03040/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Coloring Agents)
RN  - 0 (Glucocorticoids)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Coloring Agents
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Fluorescein Angiography
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Indocyanine Green
MH  - Male
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Uveomeningoencephalitic Syndrome/*diagnosis/drug therapy
MH  - Visual Acuity
PMC - PMC2903055
MID - NIHMS166956
EDAT- 2009/12/17 06:00
MHDA- 2010/03/04 06:00
PMCR- 2011/01/01
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/04 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 10.1097/IAE.0b013e3181c5970d [doi]
PST - ppublish
SO  - Retina. 2010 Jan;30(1):33-41. doi: 10.1097/IAE.0b013e3181c5970d.