PMID- 20010366
OWN - NLM
STAT- MEDLINE
DCOM- 20100305
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 11
IP  - 12
DP  - 2009 Dec
TI  - Section E6.5 of the ACMG technical standards and guidelines: chromosome studies 
      for solid tumor abnormalities.
PG  - 890-7
LID - 10.1097/GIM.0b013e3181bb7808 [doi]
AB  - PURPOSE: : Cytogenetic analysis of tumor tissue detects clonal abnormalities. The 
      information obtained from these studies is utilized for diagnosis, prognosis, and 
      patient management. METHODS: : The Working Group of the Laboratory Quality 
      Assurance Committee of the American College of Medical Genetics provides these 
      Standards and Guidelines for chromosome studies for solid tumors abnormalities as 
      a resource for clinical cytogenetic laboratories. RESULTS: : The guidelines 
      incorporate aspects of sample procurement, handling, processing, harvesting, 
      analysis, quality control, and quality assurance. It is recommended that all 
      pediatric solid tumors be studied by cytogenetic analysis when feasible due to 
      the clinical and therapeutic implications of the genetic abnormalities. 
      Cytogenetic analysis of certain adult solid tumors also provides information that 
      impacts diagnosis and therapeutics. Molecular cytogenetic analysis or 
      fluorescence in situ hybridization (FISH) may be a primary or secondary method of 
      evaluation of the tumor tissue. FISH can document a specific molecular event, 
      e.g. gene rearrangement, provide a rapid result to aid in the differential 
      diagnosis or planning of therapy, clarify chromosome anomalies, or assess gene 
      amplification. CONCLUSION: : Genetic analysis adds valuable information to the 
      understanding of and therapeutic approach to solid tumors. Laboratories may use 
      their professional judgment to make modifications or additions to these 
      guidelines.
FAU - Cooley, Linda D
AU  - Cooley LD
AD  - Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, The 
      University of Missouri Medical School Kansas City, Kansas City, Missouri, USA. 
      lcooley@cmh.edu
FAU - Mascarello, James T
AU  - Mascarello JT
FAU - Hirsch, Betsy
AU  - Hirsch B
FAU - Jacky, Peter B
AU  - Jacky PB
FAU - Rao, P Nagesh
AU  - Rao PN
FAU - Saxe, Debra
AU  - Saxe D
FAU - Rao, Kathleen W
AU  - Rao KW
CN  - Working Group of the American College of Medical Genetics (ACMG) Laboratory 
      Quality Assurance Committee
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical 
      Genetics
JID - 9815831
SB  - IM
MH  - Adult
MH  - Child
MH  - Chromosome Aberrations
MH  - Clinical Laboratory Techniques/*standards
MH  - Cytogenetic Analysis/methods/*standards
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods/standards
MH  - Karyotyping
MH  - Neoplasms/*diagnosis/*genetics
MH  - Prognosis
EDAT- 2009/12/17 06:00
MHDA- 2010/03/06 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/06 06:00 [medline]
AID - S1098-3600(21)04010-7 [pii]
AID - 10.1097/GIM.0b013e3181bb7808 [doi]
PST - ppublish
SO  - Genet Med. 2009 Dec;11(12):890-7. doi: 10.1097/GIM.0b013e3181bb7808.