PMID- 20010902
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220310
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 34
IP  - 2
DP  - 2010 Feb
TI  - Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents.
PG  - 396-400
LID - 10.1038/ijo.2009.245 [doi]
AB  - OBJECTIVE: The aim of this study was to determine if the fat accumulation in the 
      exocrine pancreas fat of obese Zucker diabetic fatty (ZDF) rodents, like that in 
      their endocrine pancreas, precedes the onset of type 2 diabetes mellitus (T2DM). 
      As the fat content of whole pancreas, but not islets, can now be measured in 
      humans by magnetic resonance spectroscopy (MRS), such measurements could be used 
      as a predictor of impending T2DM and an indication for preventive intervention. 
      ANIMALS: Obese ZDF (fa/fa) rats and lean (+/+) controls on a 6% fat diet were 
      killed at time points from 6 to 16 weeks and total pancreatic fat was measured 
      biochemically and electronmicroscopic examination of tissue for fat droplets was 
      carried out. RESULTS: Compared to lean ZDF controls, pancreatic fat was elevated 
      above lean controls from 6 to 16 weeks of age, peaking at 10 weeks of age when 
      hyperglycemia first appeared. The pancreatic profile of fat content in whole 
      pancreas paralleled that of islets. Electronmicroscopic examination identified 
      the acinar location of the fat droplets and ruled out a major contribution of 
      intrapancreatic adipocytes. CONCLUSION: The almost identical pattern of 
      triglyceride overaccumulation in the exocrine and endocrine pancreas of obese 
      rodents before the onset of T2DM suggests that MRS of the human pancreas might 
      predict T2DM in obese subjects and permit timely interventions to prevent the 
      disease.
FAU - Lee, Y
AU  - Lee Y
AD  - Touchstone Center for Diabetes Research, Department of Internal Medicine, 
      University of Texas Southwestern Medical Center, Dallas, TX, USA.
FAU - Lingvay, I
AU  - Lingvay I
FAU - Szczepaniak, L S
AU  - Szczepaniak LS
FAU - Ravazzola, M
AU  - Ravazzola M
FAU - Orci, L
AU  - Orci L
FAU - Unger, R H
AU  - Unger RH
LA  - eng
GR  - K25 HL-68736/HL/NHLBI NIH HHS/United States
GR  - R01 DK002700/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024982/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20091215
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Triglycerides)
SB  - IM
MH  - *Adiposity
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*etiology
MH  - Obesity/complications/metabolism/*pathology
MH  - Pancreas/pathology
MH  - Pancreatic Diseases/*metabolism/pathology
MH  - Rats
MH  - Rats, Zucker
MH  - Triglycerides/*metabolism
EDAT- 2009/12/17 06:00
MHDA- 2010/11/04 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - ijo2009245 [pii]
AID - 10.1038/ijo.2009.245 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2010 Feb;34(2):396-400. doi: 10.1038/ijo.2009.245. Epub 2009 
      Dec 15.