PMID- 20011463
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100303
LR  - 20211020
IS  - 1176-9351 (Electronic)
IS  - 1176-9351 (Linking)
VI  - 7
DP  - 2009 Nov 24
TI  - In silico analysis of human Telomerase Reverse Transcriptase (hTERT) gene: 
      identification of a distant homolog of Melanoma Antigen Family Gene (MAGE).
PG  - 171-81
AB  - Melanoma antigen family (MAGE) genes are widely expressed in various tumor types 
      but silent in normal cells except germ-line cells lacking human leukocyte antigen 
      (HLA) expression. Over 25 MAGE genes have been identified in different tissues, 
      mostly located in Xq28 of human chromosome and some of them in chromosome 3 and 
      15, containing either single or multiple-exons. This in silico study predicted 
      the genes on hTERT location and identified a distant relative of MAGE gene 
      located on chromosome 5. The study identified a single exon coding ~850 residues 
      polypeptide sharing ~30% homology with Macfa-MAGE E1 and hMAGE-E1. dbEST search 
      of the predicted transcript matches 5' and 3' flanking ESTs. The predicted 
      protein showed sequence homology within the MAGE homology domain 2 (MHD2). UCSC 
      genome annotation of CpG Island around the coding region reveals that this gene 
      could be silent by methylation. Affymetrix all-exon track indicates the gene 
      could be expressed in different tissues particularly in cancer cells as they 
      widely undergo a genome wide demethylation process.
FAU - Amin, Ruhul
AU  - Amin R
AD  - Department of Microbiology, University of Dhaka, Dhaka 1000, Bangladesh. 
      jesmin@univdhaka.edu
FAU - Jesmin
AU  - Jesmin
FAU - Jamil, Hasan
AU  - Jamil H
FAU - Hossain, M Anwar
AU  - Hossain MA
LA  - eng
PT  - Journal Article
DEP - 20091124
PL  - United States
TA  - Cancer Inform
JT  - Cancer informatics
JID - 101258149
PMC - PMC2791492
OTO - NOTNLM
OT  - EST
OT  - ORF
OT  - gene prediction
OT  - melanoma antigen
OT  - telomerase
EDAT- 2009/12/17 06:00
MHDA- 2009/12/17 06:01
PMCR- 2009/11/24
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2009/12/17 06:01 [medline]
PHST- 2009/11/24 00:00 [pmc-release]
AID - cin-2009-171 [pii]
AID - 10.4137/cin.s3392 [doi]
PST - epublish
SO  - Cancer Inform. 2009 Nov 24;7:171-81. doi: 10.4137/cin.s3392.