PMID- 20012082
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20100121
IS  - 1432-0770 (Electronic)
IS  - 0340-1200 (Linking)
VI  - 102
IP  - 1
DP  - 2010 Jan
TI  - Parameters for a model of an oscillating neuronal network in the cochlear nucleus 
      defined by genetic algorithms.
PG  - 81-93
LID - 10.1007/s00422-009-0353-2 [doi]
AB  - Chopper neurons in the cochlear nucleus are characterized by intrinsic 
      oscillations with short average interspike intervals (ISIs) and relative level 
      independence of their response (Pfeiffer, Exp Brain Res 1:220-235, 1966; 
      Blackburn and Sachs, J Neurophysiol 62:1303-1329, 1989), properties which are 
      unattained by models of single chopper neurons (e.g., Rothman and Manis, J 
      Neurophysiol 89:3070-3082, 2003a). In order to achieve short ISIs, we optimized 
      the time constants of Rothman and Manis single neuron model with genetic 
      algorithms. Some parameters in the optimization, such as the temperature and the 
      capacity of the cell, turned out to be crucial for the required acceleration of 
      their response. In order to achieve the relative level independence, we have 
      simulated an interconnected network consisting of Rothman and Manis neurons. The 
      results indicate that by stabilization of intrinsic oscillations, it is possible 
      to simulate the physiologically observed level independence of ISIs. As 
      previously reviewed and demonstrated (Bahmer and Langner, Biol Cybern 95:371-379, 
      2006a), chopper neurons show a preference for ISIs which are multiples of 0.4 ms. 
      It was also demonstrated that the network consisting of two optimized Rothman and 
      Manis neurons which activate each other with synaptic delays of 0.4 ms shows a 
      preference for ISIs of 0.8 ms. Oscillations with various multiples of 0.4 ms as 
      ISIs may be derived from neurons in a more complex network that is activated by 
      simultaneous input of an onset neuron and several auditory nerve fibers.
FAU - Bahmer, Andreas
AU  - Bahmer A
AD  - Clinic for Otolaryngology, Audiological Acoustics, University of Frankfurt Main, 
      60590, Frankfurt, Germany. andreas.bahmer@kgu.de
FAU - Langner, Gerald
AU  - Langner G
LA  - eng
PT  - Journal Article
DEP - 20091210
PL  - Germany
TA  - Biol Cybern
JT  - Biological cybernetics
JID - 7502533
RN  - 0 (Potassium Channels)
RN  - 0 (Sodium Channels)
SB  - IM
MH  - Algorithms
MH  - Auditory Pathways/anatomy & histology/physiology
MH  - Biological Clocks/*physiology
MH  - *Cochlear Nucleus/anatomy & histology/physiology
MH  - Computer Simulation
MH  - Humans
MH  - Models, Genetic
MH  - *Models, Neurological
MH  - *Nerve Net/anatomy & histology/physiology
MH  - Neurons/cytology/*physiology
MH  - Patch-Clamp Techniques
MH  - Potassium Channels/metabolism
MH  - Sodium Channels/metabolism
EDAT- 2009/12/17 06:00
MHDA- 2010/03/13 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/10/08 00:00 [received]
PHST- 2009/11/17 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - 10.1007/s00422-009-0353-2 [doi]
PST - ppublish
SO  - Biol Cybern. 2010 Jan;102(1):81-93. doi: 10.1007/s00422-009-0353-2. Epub 2009 Dec 
      10.